Three-dimensional (3D) finite element analysis is used in this study to model the mechanical effects of the electrode in a cochlear implant. We employ six electrodes with different stiffness produced by different arrangements of metal wires. Different wire arrangements are generated by changing the fitness function of a genetic program. The human cochlea is modeled by the spiral-approximation method. Reconstructed three-dimensional CT images are used to model the real insertion condition. The contact pressure at the tip and the insertion force are found to be highest when the wires are stacked horizontally. Axial rotation of the electrode has minimal effect on the stimulating current spread. The electrode does not contact the basilar membrane. The results indicate that considering the electrode stiffness is important to minimizing mechanical trauma in cochlear implantation.
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http://dx.doi.org/10.1016/j.medengphy.2004.12.009 | DOI Listing |
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January 2025
School of Chemistry, Institute of Science, Suranaree University of Technology, 111 University Avenue, Muang District, Nakhon Ratchasima 30000, Thailand.
Nicotinamide adenine dinucleotide is a crucial coenzyme in cellular metabolism and is implicated in various diseases. This work introduces an electrochemical bioanalytical method utilizing solution-phase formate dehydrogenase (CbFDH) for detecting its oxidized form (NAD) in human blood plasma samples. The detection mechanism involves the catalytic conversion of NAD to NADH, facilitated by CbFDH in the presence of formate.
View Article and Find Full Text PDFElectromagn Biol Med
January 2025
Department of Mathematics, University of Gour Banga, Malda, India.
In cardiovascular research, electromagnetic fields generated by Riga plates are utilized to study or manipulate blood flow dynamics, which is particularly crucial in developing treatments for conditions such as arterial plaque deposition and understanding blood behavior under varied flow conditions. This research predicts the flow patterns of blood enhanced with gold and maghemite nanoparticles (gold-maghemite/blood) in an electromagnetic microchannel influenced by Riga plates with a temperature gradient that decays exponentially, under sudden changes in pressure gradient. The flow modeling includes key physical influences like radiation heat emission and Darcy drag forces in porous media, with the flow mathematically represented through unsteady partial differential equations solved using the Laplace transform (LT) method.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Department of Environmental Engineering, Kwangwoon University, Seoul 01897, Republic of Korea.
The advancement of highly efficient and cost-effective electrocatalysts for electrochemical water splitting, along with the development of triboelectric nanogenerators (TENGs), is crucial for sustainable energy generation and harvesting. In this study, a novel hybrid composite by integrating graphitic carbon nitride (GCN) with an earth-abundant FeMg-layered double hydroxide (LDH) (GCN@FeMg-LDH) was synthesized by the hydrothermal approach. Under controlled conditions, with optimized concentrations of metal ions and GCN, the fabricated electrode, GCN@FeMg-LDH demonstrated remarkably low overpotentials of 0.
View Article and Find Full Text PDFAnal Chem
January 2025
Rural Health Research Institute, Charles Sturt University, Orange, New South Wales 2800, Australia.
The detection and analysis of circulating cell-free nucleic acid (ccfNA) biomolecules are redefining a new era of molecular targeted cancer therapies. However, the clinical translation of electrochemical ccfNA biosensing remains hindered by unresolved challenges in analytical specificity and sensitivity. In this Perspective, we present a novel electrochemical framework for improving ccfNA biosensor performance by optimizing the critical electrode-biomolecules-electrolyte interfaces.
View Article and Find Full Text PDFLab Chip
January 2025
Antwerp Engineering, Photoelectrochemistry and Sensing (A-PECS), University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium.
Wearable microfluidic sweat sensors could play a major role in the future of monitoring health and wellbeing. Sweat contains biomarkers to monitor health and hydration status, and it can provide information on drug intake, making it an interesting non-invasive alternative to blood. However, sweat is not created in excess, and this requires smart sweat collection strategies to handle small volumes.
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