The ATM/p53 pathway plays a critical role in maintenance of genome integrity and can be targeted for inactivation by a number of characterized mechanisms including somatic genetic/epigenetic alterations and expression of oncogenic viral proteins. Here, we examine a panel of 24 SCCHN tumors using various molecular approaches for the presence of human papillomavirus (HPV), mutations in the p53 gene and methylation of the ATM promoter. We observed that 30% of our SCCHN samples displayed the presence of HPV and all but one was HPV type 16. All HPV E6 gene-positive tumors exhibited E6 transcript expression. We observed 21% of the tumors harbored p53 mutations and 42% of tumors displayed ATM promoter methylation. The majority of tumors (71%) were positive for at least one of these events. These findings indicate that molecular events resulting in inactivation of the ATM/p53 pathway are common in SCCHN and can arise by a number of distinct mechanisms.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.oraloncology.2005.06.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exposure to titanium dioxide nanoparticles disrupts the BTB by interfering with the assembly of stress granules in germ cells.
J Environ Manage
December 2024
Institute of Urology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China. Electronic address:
Titanium dioxide nanoparticles (TiO NPs) are among the most prevalent nanomaterials utilized in industrial and medical fields. However, their impact on spermatogenesis and male fertility remains insufficiently characterized. This study addresses the reproductive toxicity of TiO NPs and elucidates the underlying molecular mechanisms involved.
View Article and Find Full Text PDFResin monomers induce apoptosis of the pulp-dentin complex through the mitochondrial pathway.
J Toxicol Sci
December 2024
Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, People's Republic of China.
Numerous studies have confirmed that the apoptosis induced by the methacrylate resin monomers triethyleneglycol-dimethacrylate (TEGDMA), 2-hydroxy ethyl methacrylate (HEMA), etc., in pulp cells and odontoblast-like cells is caused mainly by oxidative stress (OS). Reactive oxygen species (ROS), recognized as the most important risk factor for apoptosis in cells of the pulp-dentin complex, are produced mainly via the mitochondrial respiratory chain.
View Article and Find Full Text PDFSilica nanoparticles cause ovarian dysfunction and fertility decrease in mice via oxidative stress-activated autophagy and apoptosis.
Ecotoxicol Environ Saf
October 2024
School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, People's Republic of China; Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, Tangshan, Hebei 063210, People's Republic of China; Hebei Key Laboratory for Organ Fibrosis Research, Tangshan, Hebei 063210, People's Republic of China. Electronic address:
Silica nanoparticles (SiNPs) are widely used in various commercial applications, which inevitably increase the risk of human exposure. It's reported that SiNPs have toxic effects on fertility, however, the specific mechanism of female reproductive toxicity induced by SiNPs remains confusing. In this study, female C57BL/6 mice at the age of 8 weeks were administrated orally with SiNPs at doses of 0, 3, and 10 mg/kg bw.
View Article and Find Full Text PDFThe RIG-I-like receptor signaling pathway triggered by Staphylococcus aureus promotes breast cancer metastasis.
Int Immunopharmacol
December 2024
Inner Mongolia Key Laboratory for Molecular Regulation of the Cell, State Key Laboratory of Reproductive Regulation & Breeding of Grassland livestock, School of Life Sciences, Inner Mongolia University, Hohhot, Inner Mongolia, PR China. Electronic address:
Article Synopsis
- Host microbes like Staphylococcus aureus (S. aureus) are becoming recognized as important factors in cancer, but their specific roles, especially in breast cancer, are not fully understood.
- The study found that S. aureus infection leads to ineffective DNA damage response in breast cells, promoting tumor progression and metastasis through the activation of certain immune pathways.
- Key findings show that S. aureus triggers receptors in breast cells, which activates the NF-κB p65 pathway, ultimately facilitating breast cancer cell spread and highlighting a connection between bacterial infections and cancer metastasis.
Mechanistic insights into acetamiprid-induced genotoxicity on the myocardium and potential ameliorative role of resveratrol.
Environ Toxicol Pharmacol
September 2024
Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Article Synopsis
- The study investigated the genotoxic effects of the insecticide acetamiprid (ACP) on the heart tissue of male rats and the potential protective role of resveratrol (RSV).
- Results showed that ACP exposure led to increased DNA damage and oxidative stress in the myocardium, indicated by higher levels of micronuclei and 8-hydroxydeoxyguanosine.
- Co-treatment with RSV significantly reduced DNA damage and restored oxidative balance by enhancing antioxidant defenses and DNA repair mechanisms through specific cellular pathways.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!