AI Article Synopsis
- Neonatal maternal deprivation in rats was studied to see how it affects Nippostrongylus brasiliensis infection and the immune response.
- Rats deprived of their mothers showed increased intestinal worm counts and inflammation after the first infection compared to undisturbed rats.
- Despite these changes, the maternal deprivation did not lead to a severe breakdown in immunity after a secondary infection with the parasite.
Article Abstract
Neonatal stress is known to alter immune responses in adults and parasitic infection is modulated by the immune status of the host. The present study aimed to establish whether neonatal maternal deprivation affects the time course of Nippostrongylus brasiliensis infection and associated intestinal alterations in adult rats. Rat pups were separated from their dam 3h daily during postnatal days 2-14, or left undisturbed. At 12 weeks of age, N. brasiliensis infection was induced by subcutaneous administration of 3000 L3 larvae. At 7 and 12 days after primary infection, the number of intestinal adult worms, fecal egg output, jejunal paracellular permeability, and myeloperoxidase (MPO) activity were measured. On days 7 and 12 after a secondary infection, numbers of adult worms and egg production were determined. Maternal deprivation increased the number of jejunal adult worms and fecal eggs and larvae on day 7 after primary infection, and exacerbated the increase in jejunal MPO activity induced by the infection. On day 12, adult worms were only observed in deprived rats. N. brasiliensis infection did not potentiate the increase in jejunal paracellular permeability induced by maternal deprivation. After the second infection, no egg was detected in both control and deprived rats. In conclusion, maternal deprivation in rats facilitates primary infection by N. brasiliensis and enhances the inflammatory response of the jejunum, but does not induce severe breakdown of immunity to N. brasiliensis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbi.2005.07.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Laminin-dystroglycan mediated ferroptosis in hemorrhagic shock and reperfusion induced-cognitive impairment through AMPK/Nrf2.
Free Radic Biol Med
January 2025
Department of Anesthesiology and Perioperative Medicine, the Second Affiliated Hospital of Anhui Medical University, Hefei City, Anhui Province, China; Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei City, Anhui Province, China; Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China. Electronic address:
Hemorrhagic shock and reperfusion (HSR) is the main cause of death following trauma. Cognitive impairment may persist after successful resuscitation from hemorrhagic shock, but the mechanisms remain elusive. This study demonstrated the presence of ferroptosis in an in vitro model of oxygen-glucose deprivation and reoxygenation (OGD/R) in HT22 neurons, and also in a murine model of HSR using 3-month-old C57BL/6 mice.
View Article and Find Full Text PDFA meta-analysis of sex differences in neonatal rodent ultrasonic vocalizations and the implication for the preclinical maternal immune activation model.
Biol Sex Differ
January 2025
Department of Psychology, Memorial University of Newfoundland and Labrador, St. John's NL, Canada.
As the earliest measure of social communication in rodents, ultrasonic vocalizations (USVs) in response to maternal separation are critical in preclinical research on neurodevelopmental disorders (NDDs). While sex differences in both USV production and behavioral outcomes are reported, many studies overlook sex as a biological variable in preclinical NDD models. We aimed to evaluate sex differences in USV call parameters and determine if USVs are differently impacted based on sex in the preclinical maternal immune activation (MIA) model.
View Article and Find Full Text PDFA Retrospective Analysis Evaluating the Impact of Neighborhood Deprivation on Birth Weight in Phoenix, Arizona.
Int J Environ Res Public Health
January 2025
School of Medicine, Creighton University, 3100 N Central Ave, Phoenix, AZ 85012, USA.
Background: Health inequities begin before birth and are influenced by pregnancy conditions, race/ethnicity, social class, and environment. Research indicates that, in the United States, Black women are significantly more likely to have low-birth-weight babies compared to White women. Interestingly, Hispanic women in the United States do not experience this birth weight inequity.
View Article and Find Full Text PDFPredictors of early childhood insomnia according to parent-rated degree of severity.
Sleep Med
January 2025
Université de Paris, NeuroDiderot, INSERM, Paris, France.
This study aimed to investigate child and maternal-related predictors of Early Childhood Insomnia (ECI) based on a parent-rated severity in a convenience sample of mother-infant dyads with ECI. We conducted a single-center, cross-sectional prospective study involving infants aged 6-36 months who attended the Pediatric Behavioral Sleep Outpatient Clinic at Marmara University Hospital, Istanbul, over 5 years for ECI. Infant sleep was evaluated by Brief Infant Sleep Questionnaire.
View Article and Find Full Text PDFNeighborhood income inequality, maternal relative deprivation and neonatal health in Sweden: A cross-sectional study using individually defined multi-scale contexts.
SSM Popul Health
March 2025
Department of Education, Uppsala University, Uppsala, Sweden.
•Maternal relative deprivation is linked to intrauterine growth restriction.•Neighborhood income inequality is linked to fewer low Apgar scores in high-income mothers.•Findings support relative deprivation hypothesis over income inequality hypothesis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!