AI Article Synopsis
- The study examined the effectiveness of ACE inhibitors and ARBs in preventing new cases of type 2 diabetes, given the increasing prevalence of diabetes in the U.S.
- A meta-analysis of 12 clinical trials revealed that ACE inhibitors reduced the risk of developing diabetes by 27%, and ARBs by 23%, with a combined reduction of 25%.
- It is recommended that these medications be considered for patients at risk of diabetes, including those with conditions like metabolic syndrome, hypertension, and obesity.
Article Abstract
Objectives: We sought to investigate the role of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) in preventing the new onset of type 2 diabetes mellitus.
Background: Diabetes is a public health problem of epidemic proportions and its prevalence is on the rise. The typical American born today has a one in three chance of developing type 2 diabetes. This diagnosis is associated with an adverse cardiovascular prognosis and is considered the risk equivalent of established coronary disease. Even in high-risk individuals, diabetes is a preventable disease. Several studies have shown that ACE inhibitors and ARBs decrease the incidence of new-onset type 2 diabetes. However, the exact role of these agents in diabetes prevention has not yet been fully elucidated.
Methods: We conducted a meta-analysis of 12 randomized controlled clinical trials of ACE inhibitors or ARBs, identified through a MEDLINE search and a review of reports from scientific meetings, to study the efficacy of these medications in diabetes prevention.
Results: This showed that ACE inhibitors and ARBs were associated with reductions in the incidence of newly diagnosed diabetes by 27% and 23%, respectively, and by 25% in the pooled analysis.
Conclusions: The use of an ACE inhibitor or ARB should be considered in patients with pre-diabetic conditions such as metabolic syndrome, hypertension, impaired fasting glucose, family history of diabetes, obesity, congestive heart failure, or coronary heart disease.
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| http://dx.doi.org/10.1016/j.jacc.2005.05.051 | DOI Listing |
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