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Endo 180 participates in collagen remodeling of the periodontal ligament during orthodontic tooth movement.
BMC Oral Health
December 2024
Department of Orthodontics, Central Laboratory, Hospital for Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School, 22th Zhongguancun South Ave, Beijing, 100081, China.
Background: Orthodontic tooth movement (OTM) relies on the remodeling of periodontal tissues, including the periodontal ligament (PDL) and alveolar bone. Collagen remodeling plays a crucial role during this process, allowing for the necessary changes in the PDL's structure and function. Endo180, an urokinase plasminogen activator receptor-associated protein, is a transmembrane receptor regulated collagen remodeling.
View Article and Find Full Text PDFClinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations.
Elife
December 2024
Department of Computer Science, University of Oxford, Oxford, United Kingdom.
Sudden death after myocardial infarction (MI) is associated with electrophysiological heterogeneities and ionic current remodelling. Low ejection fraction (EF) is used in risk stratification, but its mechanistic links with pro-arrhythmic heterogeneities are unknown. We aim to provide mechanistic explanations of clinical phenotypes in acute and chronic MI, from ionic current remodelling to ECG and EF, using human electromechanical modelling and simulation to augment experimental and clinical investigations.
View Article and Find Full Text PDFAssociation of aortic root diameter and vascular function with an exaggerated blood pressure response to exercise among elite athletes.
Clin Res Cardiol
December 2024
Department of Cardiology and Angiology, Justus Liebig University Giessen, 35390, Giessen, Germany.
Background: The systolic blood pressure/workload (SBP/MET) slope was recently reported to reliably identify an exaggerated blood pressure response (eBPR) in the normal population and in athletes. We investigated whether the aortic root diameter (AoD) also correlates with an eBPR and vascular function in elite athletes.
Methods: We examined 652 healthy male elite athletes (age 25.
Bone remodeling simulation using spatial influence function in macroscopic cube case.
Front Bioeng Biotechnol
November 2024
Department of Bioengineering, Imperial College London, London, United Kingdom.
Bone has the capability to adapt its density in response to mechanical stimuli through a process known as bone remodeling, which has been simulated using various algorithms in several studies, with Strain Energy Density (SED) being a commonly used driving parameter. A spatial influence function has been introduced in addition to the remodeling algorithm, which accounts for the influence of neighboring regions on local mechanical stimuli, thereby reducing artificial mesh dependency and mimicking cellular communication in bone. However, no study has implemented the SED-driven algorithm with spatial influence function on a macroscopic 3D bone structure, and there is no physiological explanation on the value used in remodeling parameter.
View Article and Find Full Text PDFGut microbiota participates and remodels host metabolism: From treating patients to treating their gut flora.
World J Gastroenterol
December 2024
Department of Clinical Laboratory, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China.
In this editorial, we comment on Liu s article published in the recent issue of the . Biochemically and pathologically, Liu proved that the urate-lowering activity of leech total protein (LTP) was mainly attributed to the rectification of gut microbiota. Specifically, we noticed the change in and after LTP administration.
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