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Sequential Co-infection of Heligmosomoides polygyrus and Mycobacterium tuberculosis Determine Lung Macrophage Polarization and Histopathological Changes.
Indian J Tuberc
July 2021
Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan.
Background: Tuberculosis is a chronic infection caused by Mycobacterium tuberculosis (M.tb), which needs proper macrophage activation for control. It has been debated whether the co-infection with helminth will affect the immune response to mycobacterial infection.
View Article and Find Full Text PDFUrinary podocyte and TGF-β1 mRNA as markers for disease activity and progression in anti-glomerular basement membrane nephritis.
Nephrol Dial Transplant
November 2017
First Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan.
Background: Podocyte depletion causes glomerulosclerosis, with persistent podocyte loss being a major factor driving disease progression. Urinary podocyte mRNA is potentially useful for monitoring disease progression in both animal models and in humans. To determine whether the same principles apply to crescentic glomerular injury, a rat model of anti-glomerular basement membrane (anti-GBM) nephritis was studied in parallel with a patient with anti-GBM nephritis.
View Article and Find Full Text PDFCOMPARE and Pediatric Heart Network Investigator trials: Losartan finally validated in humans with Marfan, but much work remains!
Glob Cardiol Sci Pract
March 2015
Qatar Cardiovascular Research Center, Doha, Qatar.
A landmark study by Habashi et al(1) in 2006 documented for the first time both the prevention and reversal of structural changes in the aorta associated with Marfan syndrome, via pharmacological means. This study, carried out in a rat model, concluded that such results were due to an inhibitor effect by the drug losartan on TGB-β1 (Figure 1). Habashi's paper prompted some physicians, in the absence of human trials, to begin the clinical off-label use of losartan on Marfan patients, arguing that this was justified due to the drug's excellent safety profile.
View Article and Find Full Text PDFTGF-β1 expression in kidney allograft protocol biopsies during cyclosporine A therapy.
Int J Artif Organs
January 2013
Division of Nephrology, Department of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Background: TGF-β1 expression has been described to increase along with time from transplantation and has also been linked to allograft dysfunction and toxic effects of cyclosporine. Our aim was to correlate intragraft TGF-β1 expression with cyclosporine exposure after kidney transplantation.
Methods: Altogether 53 kidney allograft protocol biopsies from 42 patients on a low-dose cyclosporine-based regimen obtained at 3, 6, and 12 months were classified according to Banff and the chronic allograft damage index (CADI).
[Effects of TGB-beta1 on schwann cells in peripheral nerve regeneration].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
June 2004
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