Background: The incidence of classic Kaposi's sarcoma (CKS) in northern Sardinia is one of the highest in the world.
Methods: Sixty-two patients with CKS were typed for class I and class II antigens. All patients had been born and were living in northern Sardinia.
Results: In the Sardinian patients, we observed a positive CKS association with Cw7, DRB1*1104, DRB1*1302, DQA1*0302, and DQB1*0604, and a negative CKS association with A30, B58, Cw5, DRB1*1601, and DQB1*0502.
Conclusions: The strong positive CKS association with DRB1*1104 and DQB1*0604 and negative association with B58 are particularly significant and further support the notion of a genetic predisposition to CKS.
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| http://dx.doi.org/10.1111/j.1365-4632.2004.02206.x | DOI Listing |
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