AI Article Synopsis
- Preductal was administered alongside antibacterial therapy to 30 patients with severe pulmonary tuberculosis to assess its effects on hemodynamic disorders.
- Clinical evaluations, including electrocardiograms and echocardiograms, showed that preductal improved left ventricular function and central hemodynamics, with notable decreases in end-systolic volume and increases in ejection fraction.
- However, it did not significantly impact right ventricular dysfunction related to chronic cor pulmonale.
Article Abstract
To treat hemodynamic disorders, preductal was used in combination with antibacterial therapy in 30 patients with disseminated destructive pulmonary tuberculosis for a month. A control group comprising 31 patients was in parallel observed. Clinical, electrocardiographic, and echocardiographic studies were performed to evaluate the efficacy of preductal. The drug was found to promote improvements in left ventricular function and central hemodynamics as a decrease in end-systolic volume and increases in ejection fraction and stroke and minute volumes. Preductal exerted no significant effect on right ventricular dysfunction associated with chronic cor pulmonale.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Acute maternal hyperoxygenation to predict hypoxia and need for emergency intervention in fetuses with transposition of the great arteries: a pilot study.
J Am Soc Echocardiogr
January 2025
Department of Congenital Heart Disease, Evelina London Children's Hospital, Guy's & St Thomas' NHS Trust, Westminster Bridge Road, London SE1 7EH, UK; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Background: Newborns with transposition of the great arteries (TGA) are at risk of severe hypoxia from inadequate atrial mixing, closure of the arterial duct and/or pulmonary hypertension (PPHN). Acute maternal hyperoxygenation (AMH) might assist in identifying at-risk fetuses. We report pulmonary vasoreactivity to AMH in TGA fetuses and its relationship to early postnatal hypoxia and requirement for emergency balloon atrial septostomy (e-BAS).
View Article and Find Full Text PDFFetal-to-Neonatal Transition of an Infant with Transposition of the Great Arteries and Intact Ventricular Septum: A Case Report.
Biomed Hub
December 2024
Division of Paediatric Cardiology, Department of Paediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Centre (LUMC), Leiden, The Netherlands.
Introduction: Transposition of the great arteries (TGA), especially with intact ventricular septum (TGA-IVS), presents unique challenges during fetal-to-neonatal transition, which can contribute to developing persistent pulmonary hypertension of the newborn (PPHN).
Case Presentation: A male newborn with TGA-IVS, delivered via caesarean section, presented with hypoxemia and tachycardia immediately after birth (preductal SpO: 50-60%, post-ductal SpO: 70-75%). Echocardiography revealed a floppy interatrial septum and two interatrial connections with bidirectional shunting.
Oxygen saturation in healthy-term neonates at high altitude: A multisite prospective study.
Paediatr Child Health
November 2024
Pediatrics, University of Calgary and Alberta Health Services, Calgary, Alberta, Canada.
Objectives: To determine oxygen saturation (SpO) values and their variability in healthy-term neonates at high altitude.
Methods: In a prospective multisite, non-randomized blinded study, we performed SpO measurements in healthy neonates admitted to postnatal wards and followed up in Public Health Nurse Clinics (PHNC) in Calgary, Alberta, Canada. We recruited healthy-term neonates (≥37 weeks) between 6 and 24 h of age.
Reference Ranges for Preductal Oxygen Saturation and Heart Rate in Moderate and Late Preterm Infants with Deferred Cord Clamping.
Neonatology
November 2024
Neonatal Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain.
Introduction: Moderate and late preterm (MLPT) infants represent a substantial percentage of all preterm infants and frequently need support in the delivery room. Deferred cord clamping (DCC) improves SpO2 and heart rate (HR) stabilization in term infants. However, data on MLPT infants are limited.
View Article and Find Full Text PDFRapid oxygen titration following cardiopulmonary resuscitation mitigates cerebral overperfusion and striatal mitochondrial dysfunction in asphyxiated newborn lambs.
J Cereb Blood Flow Metab
November 2024
The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia.
Asphyxiated neonates must have oxygenation rapidly restored to limit ongoing hypoxic-ischemic injury. However, the effects of transient hyperoxia after return of spontaneous circulation (ROSC) are poorly understood. We randomly allocated acutely asphyxiated, near-term lambs to cardiopulmonary resuscitation in 100% oxygen ("standard oxygen", n = 8) or air (n = 7) until 5 minutes after ROSC, or to resuscitation in 100% oxygen immediately weaned to air upon ROSC ("rapid-wean", n = 7).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!