Objective: To study the effect of vascular endothelial cell growth factor (VEGF) on repair of bone defect with cortical bone allograft.
Methods: Forty five New Zealand white rabbits, weighted 2.5-3.0 kg, were made bone defect model of 1.5 cm in length in the bilateral radii and then were randomly divided into 3 groups. The defect was repaired with only cortical bone allograft in the control group, with the cortical bone allograft and local injection of human recombinant VEGF in the experimental group, and with the cortical bone allograft and abdominal injection of VEGF PAb3 in the antagonist group. Roentgenography, immunohistochemical staining and tetracycline labelling were carried out to evaluate the reparative results 1, 3, 5, 8 and 16 weeks after operation.
Results: Immunohistochemical staining results showed that a great deal of blood vessels formed in the experimental group, and the number of blood vessels increased gradually with the time and reached the highest value at the 8th week. Tetracycline labelling showed the same result. The best results in callus formation, ossification rate and count of microvascular density were shown in the experimental group, while those in the control group were significantly better than those in the antagonist group (P < 0.05), but there was no significant difference between the experimental group and the control group at the 8th week and the 16th week (P > 0.05).
Conclusion: VEGF can accelerates the bone formation and angiogenesis in the bone allografts, thus it can promote the repair of bone defects.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The Multifactorial Relationship Between Bone Tissue Water and Stiffness at the Proximal Femur.
Calcif Tissue Int
January 2025
Department of Bioengineering, Temple University, 1947 N. 12th St, Philadelphia, PA, 19122, USA.
Bone mechanical function is determined by multiple factors, some of which are still being elucidated. Here, we present a multivariate analysis of the role of bone tissue composition in the proximal femur stiffness of cadaver bones (n = 12, age 44-93). Stiffness was assessed by testing under loading conditions simulating a sideways fall onto the hip.
View Article and Find Full Text PDFFinite Element Analysis of Functionally Loaded Subperiosteal Implants Evaluated on a Realistic Model Reproducing Severe Atrophic Jaws.
Methods Protoc
January 2025
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40125 Bologna, Italy.
Implant-supported prosthetic rehabilitation for patients with severely atrophic jaws is challenging due to complex anatomical considerations and the limitations of conventional augmentation techniques. This study explores the potential of subperiosteal (juxta-osseous) implants as an alternative solution, using finite element analysis (FEA) to evaluate mechanical performance. Realistic jaw models, developed from radiographic data, are utilized to simulate various implant configurations and load scenarios.
View Article and Find Full Text PDFLife history and growth dynamics of a peirosaurid crocodylomorph (Mesoeucrocodylia; Notosuchia) from the Late Cretaceous of Argentina inferred from its bone histology.
J Anat
January 2025
Museo Argentino de Ciencias Naturales "Bernardino Rivadavia", CONICET, Buenos Aires, Argentina.
Notosuchia were a successful lineage of Crocodyliformes that achieved a remarkable diversity during the Cretaceous of Gondwana, particularly in South America. Although paleohistology has expanded our knowledge of the paleobiology of notosuchians, several clades of this lineage remain poorly understood in this aspect. Here we help to address this gap by conducting the first histological analysis of appendicular bones of a peirosaurid.
View Article and Find Full Text PDF3D MRI with CT-like bone contrast (3D-BONE): a pictorial review of clinical applications.
Acta Radiol
January 2025
Department of Radiology, Changi General Hospital, Singapore, Republic of Singapore.
Background: Computed tomography (CT) is the gold standard imaging modality for the assessment of 3D bony morphology but incurs the cost of ionizing radiation exposure. High-resolution 3D magnetic resonance imaging (MRI) with CT-like bone contrast (CLBC) may provide an alternative to CT in allowing complete evaluation of both bony and soft tissue structures with a single MRI examination.
Purpose: To review the technical aspects of an optimized stack-of-stars 3D gradient recalled echo pulse sequence method (3D-Bone) in generating 3D MR images with CLBC, and to present a pictorial review of the utility of 3D-Bone in the clinical assessment of common musculoskeletal conditions.
Bone imaging modality precision and agreement between DXA, pQCT, and HR-pQCT.
JBMR Plus
February 2025
Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia.
Quantifying precision error for DXA, peripheral QCT (pQCT), and HR-pQCT is crucial for monitoring longitudinal changes in body composition and musculoskeletal outcomes. Agreement and associations between bone variables assessed using pQCT and second-generation HR-pQCT are unclear. This study aimed to determine the precision of, and agreement and associations between, bone variables assessed via DXA, pQCT, and second-generation HR-pQCT.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!