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Sustained progression and loss of the gender-related difference in atherosclerosis in the very old: a pathological study of 1074 consecutive autopsy cases. | LitMetric

AI Article Synopsis

  • The study examines the progression of atherosclerosis in very old individuals (average age 80) to understand gender differences in cardiovascular mortality.
  • Autopsy data from 1074 cases revealed that while atherosclerosis severity increases with age, the male predominance in severity decreases significantly after the 90s.
  • The findings suggest ongoing atherosclerosis progression, with implications for increased cardiovascular mortality rates in elderly females, highlighting the need for continued prevention efforts into older age.

Article Abstract

Introduction: Epidemiological surveys show decrease or reversal of male predominance in cardiovascular mortality in the very old, but the actual condition of atherosclerosis in the very old is largely unknown. The objective of this paper is to reveal whether the atherosclerosis continues to progress, or the gender-related difference exists in the very old.

Methods: The subjects were 1074 consecutive autopsy cases of in-hospital death. The male:female ratio was 1.1:1 and the average age was 80 years. Macroscopic evaluation was performed on the degree of atherosclerosis in 10 arteries including the intracranial arteries, carotid artery, aorta, coronary artery, and femoral artery.

Results: The severity of atherosclerosis differed greatly among arteries. The age-related increase of the atherosclerotic degree was evident, even after 80 years of age. The atherosclerosis was more severe in males than in females in their 60s, but this male predominance decreased with ageing and finally disappeared in their 90s.

Conclusion: The sustained progression of atherosclerosis and loss of the gender-related difference probably account for the increase of cardiovascular mortality in very old females. They also suggest that the prevention of the atherosclerotic progression is still important in the seventh and eighth decade of life.

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Source
http://dx.doi.org/10.1016/j.atherosclerosis.2005.07.023DOI Listing

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