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Serological evidence of Crimean-Congo haemorrhagic fever in domestic animals from eight regions of Namibia.
Acta Trop
January 2025
Dept. of Animal Medicine, Production and Health, University of Padova, Legnaro, viale dell'Università 16, 35020, Italy. Electronic address:
Crimean-Congo haemorrhagic fever (CCHF) is a viral zoonotic disease endemic to regions of Africa, the Balkans, the Middle East, and Asia, with increasing reports of cases in southern Europe. Human transmission occurs primarily through the bite of infected ticks and by body fluids from infected human. Crimean-Congo haemorrhagic fever virus (CCHFV) affects a broad host range, including both domestic and wild vertebrates.
View Article and Find Full Text PDFAnalysis of 1386 epileptogenic brain lesions reveals association with DYRK1A and EGFR.
Nat Commun
November 2024
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Lesional focal epilepsy (LFE) is a common and severe seizure disorder caused by epileptogenic lesions, including malformations of cortical development (MCD) and low-grade epilepsy-associated tumors (LEAT). Understanding the genetic etiology of these lesions can inform medical and surgical treatment. We conducted a somatic variant enrichment mega-analysis in brain tissue from 1386 individuals who underwent epilepsy surgery, including 599 previously unpublished individuals with ultra-deep ( > 1600x) targeted panel sequencing.
View Article and Find Full Text PDFTC10 differently controls the dynamics of Exo70 in growth cones of cortical and hippocampal neurons.
Biophys Rep (N Y)
December 2024
Institute of Integrative Cell Biology and Physiology, Department of Biology, University of Muenster, Münster, North-Rhine-Westphalia, Germany. Electronic address:
The exocyst is an octameric protein complex that acts as a tether for GOLGI-derived vesicles at the plasma membrane during exocytosis. It is involved in membrane expansion during axonal outgrowth. Exo70 is a major subunit of the exocyst complex and is controlled by TC10, a Rho family GTPase.
View Article and Find Full Text PDFIncreased exercise tolerance in humanized G6PD deficient mice.
Blood Adv
November 2024
University of Colorado Denver - Anschutz Medical Campus, Denver, Colorado, United States.
Article Synopsis
- - Glucose-6-phosphate dehydrogenase (G6PD) deficiency, affecting 500 million people, impairs red blood cell antioxidant functions, raising the risk of hemolysis during oxidative stress, particularly during exercise.
- - A study using mice with a specific G6PD variant showed that, despite lower enzyme activity, these mice had better exercise performance and improved heart function post-exercise compared to normal mice.
- - Analysis revealed enhanced mitochondrial function and changes in energy metabolism and protein turnover, indicating that G6PD-deficient individuals might have a metabolic advantage during exercise, challenging existing beliefs about hemolytic risks.
Transcriptome Profiling Associated with Overexpression in Colorectal Cancer Implicates a Potential Role for Tumor Immune Microenvironment and Cancer Pathways Modulation via NF-κB.
Int J Mol Sci
September 2024
Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
The immune system plays a critical role in inflammation by initiating responses to infections or tissue damage. The nuclear factor-κB (NF-κB) pathway plays a key role in inflammation and innate immunity, as well as other cellular activities. Dysregulation of this well-choreographed pathway has been implicated in various diseases, including cancer.
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