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Vaccination as a Promising Approach in Cardiovascular Risk Mitigation: Are We Ready to Embrace a Vaccine Strategy?
Biomolecules
December 2024
Diabetes Center, First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece.
Cardiovascular disease (CVD) remains a leading global health concern, with atherosclerosis being its principal cause. Standard CVD treatments primarily focus on mitigating cardiovascular (CV) risk factors through lifestyle changes and cholesterol-lowering therapies. As atherosclerosis is marked by chronic arterial inflammation, the innate and adaptive immune systems play vital roles in its progression, either exacerbating or alleviating disease development.
View Article and Find Full Text PDFThe interaction of a self-assembled nanoparticle and a lipid membrane: Binding, disassembly and re-distribution.
Heliyon
November 2024
Department of Chemistry, University of the Balearic Islands, Ctra. Valldemossa, Km 7.5. 07122, Palma de Mallorca, Spain.
Here we report a detailed study of the interactions of nanoparticles, formed by the self-assembly of cholesterol-containing porphyrins, with lipid membranes. We show that the interaction is a two-step process: first, the docking and fusion, then, the redistribution of the building blocks of the self-assembled nanoparticles (SANs henceforth). Analysis of the binding and structural data is consistent with the docking step being driven by a multivalence cooperative effect and with the formation of SAN aggregates on the membrane, whilst the solubility of the cholesterol anchor in the membrane is key to both the fusion and redistribution of the SANs building blocks.
View Article and Find Full Text PDFFrom LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism.
Biochim Biophys Acta Mol Cell Biol Lipids
January 2025
Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address:
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver pathology worldwide, closely associated with obesity and metabolic disorders. Increasing evidence suggests that macrophages play a crucial role in the development of MASLD. Several human studies have shown an inverse correlation between circulating lysosomal acid lipase (LAL) activity and MASLD.
View Article and Find Full Text PDFPH-Triggered, Lymph Node Focused Immunodrug Release by Polymeric 2-Propionic-3-Methyl-maleic Anhydrides with Cholesteryl End Groups.
Adv Healthc Mater
December 2024
Chair of Macromolecular Chemistry, Julius-Maximilians-Universität Würzburg, 97070, Würzburg, Germany.
Article Synopsis
- The text discusses the importance of targeting immune activation in specific areas for effective vaccine delivery and cancer treatment without causing unwanted immune reactions throughout the body.
- It introduces cholesterol-based polymers that respond to pH changes, providing a way to control the release of immunoactivating substances specifically at lymph nodes.
- The results showed that these pH-sensitive polymers could enhance the number of fully matured immune cells in the lymph nodes after being injected, making them a promising option for delivering immune drugs effectively.
Association of Gene Polymorphisms and Haplotypes with Acute Heart Rate Response to Exercise.
Int J Mol Sci
August 2024
Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Polymorphisms in the cholesteryl ester transfer protein () gene are known to be strongly associated with increased cardiovascular risk, primarily through their effects on the lipid profile and consequently on atherosclerotic risk. The acute heart rate response (AHRR) to physical activity is closely related to individual cardiovascular health. This study aimed to investigate the effect of gene polymorphisms on AHRR.
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