Inversion of transverse relaxation time decay curve from spin-echo experiments was carried out using Hopfield neural network, to obtain the transverse relaxation time distribution. The performance of this approach was tested against simulated and experimental data. The initial guess, necessary for the integration procedure, was established as the analytical Laplace inversion. Together with errors in the simulated data, inversion was also carried out with errors in this initial guess. The probability density function, calculated by the neural network, is used in multiple sclerosis diagnostics.
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http://dx.doi.org/10.1016/j.jmr.2005.07.017 | DOI Listing |
Biomol NMR Assign
January 2025
Department of Chemistry, Iowa State University, Hach Hall, 2438 Pammel Drive, Ames, IA, 50011, USA.
The Alkbh7 protein, a member of the Alkylation B (AlkB) family of dioxygenases, plays a crucial role in epigenetic regulation of cellular metabolism. This paper focuses on the NMR backbone resonance assignment of Alkbh7, a fundamental step in understanding its three-dimensional structure and dynamic behavior at the atomic level. Herein, we report the backbone H, N, C chemical shift assignment of the full-length human Alkbh7.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
University of New Brunswick, UNB MRI Centre, Department of Physics, Fredericton, New Brunswick, E3B 5A3, Canada.
We observe divergent temperature-dependent magnetic resonance relaxation behaviors across various brine-saturated porous materials. The paramagnetic and diamagnetic nature of the samples underlies these divergent behaviors. The temperature-dependent trends of the longitudinal T_{1} and transverse T_{2} relaxation times are systematically explained via distinct relaxation-diffusion regimes of Brownstein-Tarr theory.
View Article and Find Full Text PDFFront Musculoskelet Disord
March 2024
Department of Radiology, University of California, San Diego, San Diego, CA, United States.
Tendon disease ranks among the leading reasons patients consult their general practitioners, comprising approximately one-third of musculoskeletal appointments. Magnetic resonance imaging (MRI) is regarded as the gold standard for assessing tendons. Due to their short transverse relaxation time (T2), Tendons show up as a signal void in conventional MRI scans, which employ sequences with echo times (TEs) around several milliseconds.
View Article and Find Full Text PDFJ Physiol Sci
January 2025
Department of Rehabilitation, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, 321-0293, Tochigi, Japan. Electronic address:
The purpose of this study was the detection and characterization of synergistic muscle activity. Using T-map MRI, T values for 10 forearm muscles in 11 healthy adult volunteers were obtained in the resting state and after isotonic forearm supination and pronation exercises with the elbow extended. T was normalized by Z = (T-T)/SD, where T was T after exercise, while T and SD were the reference values of 34 ms and 3 ms, respectively.
View Article and Find Full Text PDFFront Psychiatry
January 2025
Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA, United States.
Background: Psychotic disorders are characterized by white matter (WM) abnormalities; however, their relationship with the various aspects of illness presentation remains unclear. Sleep disturbances are common in psychosis, and emerging evidence suggests that sleep plays a critical role in WM physiology. Therefore, it is plausible that sleep disturbances are associated with impaired WM integrity in these disorders.
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