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Frozen/Thawed Samples Can Replace Fresh Samples for Assignment of ISI to Secondary Thromboplastin Standards for Multiple Reagent/Instrument Combinations: Data to Support Possible Revision of WHO Guidelines.
Int J Lab Hematol
February 2025
Coagulation Department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, England.
Background: Calibration of thromboplastins is required for accurate calculation of the international normalised ratio (INR). Accurate INR results are required for optimal dosing of vitamin K antagonists. Decreases in vitamin K antagonist usage have made the recruitment of sample sets for international sensitivity index (ISI) calibrations more difficult.
View Article and Find Full Text PDFEstimating the measurement uncertainties of the international sensitivity index of 12 thromboplastins through Monte Carlo simulation.
Thromb Res
April 2023
Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, South Korea. Electronic address:
Background: Measurement uncertainty (MU) estimation has become an important process in clinical laboratories; however, calculating the MUs of the international sensitivity index (ISI) of thromboplastins is difficult because of the complex mathematical calculations required in calibration. Therefore, this study quantifies the MUs of ISIs through the Monte Carlo simulation (MCS), which involves random sampling of numerical values to solve a complex mathematical calculation.
Methods: Eighty blood plasmas and commercially available certified plasmas (ISI Calibrate) were used to assign the ISIs of each thromboplastin.
Effect of silymarin on blood coagulation profile and osmotic fragility in carbon tetrachloride induced hepatotoxicity in male Wistar rats.
Toxicol Rep
June 2022
Department of Physiology, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria.
Reports about the impact of Carbon tetrachloride (CCl) hepatotoxicity on coagulation profile have been inconsistent. Multiple investigators have however demonstrated the effectiveness of silymarin in the resolution of anomalies induced by CCl, although the effect of silymarin on the impact of CCl hepatotoxicity, especially coagulation profile and osmotic fragility have not been investigated. The liver, the primary site for the secretion of coagulation proteins, can become impaired in CCl hepatotoxicity, and silymarin reportedly increases hepatic protein synthesis as part of its hepatoprotective mechanism.
View Article and Find Full Text PDFBackground: To evaluate the effect of the hepatitis B virus (HBV) on the coagulation parameters in patients with hepatitis B virus-related decompensated cirrhosis (HBV-DeCi).
Methods: A retrospective analysis was conducted on the medical records of 112 patients with HBV-DeCi. Baseline clinical and laboratory characteristics were retrieved.
Association between ion shift index and prognosis in severe trauma patients without isolated head injury.
Injury
May 2021
Department of Emergency Medicine, Chonnam National University Hospital, 42 Jebong-ro, Donggu, Gwangju, Republic of Korea. Electronic address:
Introduction: This study aimed to investigate the ion shift index (ISI) as a prognostic factor of severe trauma. We hypothesized that the initial ISI measured in the emergency department (ED) is associated with discharge survival in severe non-isolated head injury (IHI) patients.
Materials And Methods: This retrospective observational study included severe trauma patients with available medical records from January 2017 to December 2018 but excluded those with IHI.
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