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False HbA value due to a rare variant of hemoglobin Petie Salpetriere coinherited with alpha thalassemia.
Adv Lab Med
December 2024
Department of Laboratory Service, Área de Gestión Sanitaria Norte de Huelva, Hospital de Riotinto, Minas de Riotinto, Huelva, Spain.
Objectives: To describe a variant hemoglobin that interferes with HbA analysis by cation exchange HPLC.
Case Presentation: A 78 years-old Spanish male patient visited the Internal Medicine Clinic for a routine check-up, with HbA included to screen for diabetes. He had suffered hypertension and dyslipidemia, and the patient had no previous symptoms suggestive of diabetes such as hyperglycemia, weight loss, polydipsia, polyuria or tiredness.
Who and how to screen for endogenous hypercortisolism in type 2 diabetes mellitus or obesity.
J Endocrinol Invest
October 2024
Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy.
Article Synopsis
- The review explores the prevalence of hypercortisolism (Cushing's syndrome) in individuals with diabetes and obesity, aiming to determine if screening is needed for these populations.
- It finds that Cushing's syndrome prevalence in type 2 diabetes patients ranges from 0.6% to 9.3%, with the overnight dexamethasone suppression test being the most common but with notable false positive rates.
- The study concludes that clinical judgment is crucial for screening decisions, with the overnight dexamethasone test recommended for diabetes patients, while late-night salivary cortisol tests are also viable for obese patients.
Plasma Steroid Profiling Between Patients With and Without Diabetes Mellitus in Nonfunctioning Adrenal Incidentalomas.
J Endocr Soc
July 2024
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Context: Adrenal incidentalomas, including nonfunctioning adrenal incidentalomas (NFAI), are associated with a high prevalence of diabetes mellitus (DM). While NFAI is diagnosed by exclusion when no hormone excess exists, subtle cortisol secretion may exist and contribute to DM development. However, it alone cannot explain the increased risk, and whether other steroid metabolites are involved remains unclear.
View Article and Find Full Text PDFInflammatory and endothelial host responses in community-acquired pneumonia: exploring the relationships with HbA1c, admission plasma glucose, and glycaemic gap-a cross-sectional study.
Front Immunol
June 2024
Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital - North Zealand, Hilleroed, Denmark.
Introduction: Diabetes is associated with dysregulated immune function and impaired cytokine release, while transient acute hyperglycaemia has been shown to enhance inflammatory cytokine release in preclinical studies. Although diabetes and acute hyperglycaemia are common among patients with community-acquired pneumonia (CAP), the impact of chronic, acute, and acute-on-chronic hyperglycaemia on the host response within this population remains poorly understood. This study investigated whether chronic, acute, and acute-on- chronic hyperglycaemia are associated with distinct mediators of inflammatory, endothelial, and angiogenic host response pathways in patients with CAP.
View Article and Find Full Text PDFMetabolomics for early pancreatic cancer detection in plasma samples from a Swedish prospective population-based biobank.
J Gastrointest Oncol
April 2024
Department of Surgical and Perioperative Sciences/Surgery, Umeå University, Umeå, Sweden.
Background: Pancreatic ductal adenocarcinoma (pancreatic cancer) is often detected at late stages resulting in poor overall survival. To improve survival, more patients need to be diagnosed early when curative surgery is feasible. We aimed to identify circulating metabolites that could be used as early pancreatic cancer biomarkers.
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