AI Article Synopsis
- - Recent studies in *Cell* and *Molecular Cell* reveal how the antibiotic streptolydigin inhibits bacterial RNA polymerase, a common target for antibiotics.
- - Streptolydigin might stop changes to a "bridge" alpha helix, which is essential for RNA polymerase's process of adding nucleotides.
- - The antibiotic may also obstruct the movements of this bridge helix that are needed for incorporating nucleotide triphosphates into the enzyme's active site.
Article Abstract
Bacterial RNA polymerase is a common target for many antibiotics. In two recent papers in Cell and Molecular Cell, and describe a structural basis for inhibition of bacterial RNA polymerase by the antibiotic streptolydigin. Streptolydigin may prevent distortion of a "bridge" alpha helix postulated to occur during the nucleotide addition cycle of RNA polymerase or may block a small movement of the bridge helix that helps load nucleotide triphosphates into the active site.
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| http://dx.doi.org/10.1016/j.cell.2005.08.008 | DOI Listing |
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