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Nitrogen Oxide (NO) in the Pathogenesis of Preeclampsia.
Bull Exp Biol Med
October 2024
Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
The concentrations of nitric oxide (NO) donors in the plasma of pregnant women with preeclampsia is several times higher than in healthy pregnant women. Antihypertensive drugs acting not through the NO-mediated mechanisms normalized BP in some women with preeclampsia, but did not significantly reduce the levels of NO donors in the plasma. It appears that preeclampsia is associated with insufficient NO availability for the targets, rather than low intensity of NO synthesis.
View Article and Find Full Text PDFStructure, properties, and decomposition in biological systems of a new nitrosyl iron complex with 2-methoxythiophenolyls, promising for the treatment of cardiovascular diseases.
J Inorg Biochem
January 2025
Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Moscow region, prosp. Akad. Semenova, 1, 142432 Chernogolovka, Russian Federation; Faculty of Fundamental Physical and Chemical Engineering, Lomonosov Moscow State University M.V. Lomonosov, Leninskie gory, 1, 119991 Moscow, Russian Federation; Scientific and Educational Center "Medical Chemistry" in Chernogolovka, Federal State Autonomous Educational Institution of Higher Education "State University of Education", Moscow Region, st. Vera Voloshina, 24, 141014 Mytishchi, Russian Federation.
A new promising binuclear tetranitrosyl iron complex with 2-methoxythiophenolyl of the composition [Fe(CHOS)(NO)] (complex 1), which acts on the therapeutic targets of cardiovascular diseases, guanylate and adenylate cyclase, has been synthesized. X-ray diffraction data show the presence of two isoforms of complex 1; according to quantum chemical calculations, the structure of only the trans isomer is stable in solutions. The processes of transformation of complex 1 in DMSO, in aqueous solutions, as well as in the presence of bovine serum albumin, reduced glutathione, and mucin were studied.
View Article and Find Full Text PDFEffect of Nitrosyl Iron Complex with 3,4-Dichlorothiophenolyls on the Level of Cyclic Nucleotide In Vitro.
Bull Exp Biol Med
June 2024
Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.
The effect of a promising NO donor, a binuclear nitrosyl iron complex (NIC) with 3,4-dichlorothiophenolyls [Fe(SCHCl)(NO)], on the adenylate cyclase and soluble guanylate cyclase enzymatic systems was studied. In in vitro experiments, this complex increased the concentration of important secondary messengers, such as cAMP and cGMP. An increase of their level by 2.
View Article and Find Full Text PDFEffects of Nitrosyl Iron Complexes with Thiol, Phosphate, and Thiosulfate Ligands on Hemoglobin.
Int J Mol Sci
June 2024
Bach Institute of Biochemistry, Federal Research Center of Biotechnology, Russian Academy of Sciences, Moscow 119071, Russia.
Nitrosyl iron complexes are remarkably multifactorial pharmacological agents. These compounds have been proven to be particularly effective in treating cardiovascular and oncological diseases. We evaluated and compared the antioxidant activity of tetranitrosyl iron complexes (TNICs) with thiosulfate ligands and dinitrosyl iron complexes (DNICs) with glutathione (DNIC-GS) or phosphate (DNIC-PO) ligands in hemoglobin-containing systems.
View Article and Find Full Text PDFInsight into the photodynamic mechanism and protein binding of a nitrosyl iron-sulfur [FeS(NO)] cluster.
Spectrochim Acta A Mol Biomol Spectrosc
November 2024
Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry and Key Laboratory of Energy Conversion and Storage Materials of Shanxi Provence, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China. Electronic address:
Article Synopsis
- The study investigates how iron-sulfur clusters and their modifications play a key role in biological signaling processes through photo-induced dynamics.
- Using advanced techniques like time-resolved EPR and MS spectra, researchers monitored the reactions and identified at least three important intermediates formed during the process.
- The findings highlight how the [FeS(NO)] cluster interacts with ferritin, ultimately leading to a specific binding state that could enhance our understanding of its physiological effects.
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