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Comprehensive Approach to Cytomorphology in Liquid-Based Bile Duct Brush Cytology: Integrating Cell Blocks and Histology.
Diagn Cytopathol
January 2025
Department of Pathology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Bile duct brush cytology is a widely used and essential method for evaluating biliary tract lesions, although it remains challenging for pathologists. Liquid-based preparations provide a better vision of morphology and enable the preparation of cell blocks, thereby enhancing reliability. However, the establishment of reproducible interpretation criteria and utilization of cell blocks remain limited.
View Article and Find Full Text PDFCytological features of oncocytic pleomorphic adenoma of the salivary gland: Using the Milan classification system to report 3 patients.
Mol Clin Oncol
March 2025
Department of Pathology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569-8686, Japan.
Pleomorphic adenoma (PA) is the most common salivary gland tumour. Pre-operative fine-needle aspiration (FNA) is currently one of the most widely used cytological examination techniques for the diagnosis of salivary gland tumours. Because PA exhibits characteristic cytological features, cytological diagnosis is straightforward in most cases.
View Article and Find Full Text PDFCluster Analysis of HCC Prognosis Using Preoperative AFP and DCP Levels: A Multi-Institutional Study.
J Gastrointest Surg
January 2025
Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University, Hiroshima University, Hiroshima, Japan.
Background: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, characterized by high recurrence rates post-curative resection. Tumor markers des-gamma-carboxy prothrombin (DCP) and alpha-fetoprotein (AFP) are crucial for HCC diagnosis and prognosis, yet their roles in the modern era of HCC epidemiology require reevaluation.
Methods: This multi-institutional retrospective study analyzed 1,515 patients who underwent hepatectomy for primary HCC.
Multidimensional Analysis of Preoperative Patient-Reported Outcomes Identifies Distinct Phenotypes in Total Knee Arthroplasty: Secondary Analysis of the SHARKS Registry in a Public Hospital Department.
J Knee Surg
January 2025
Department of Orthopaedics, QEII Jubilee Hospital, Coopers Plains, Queensland, Australia.
Traditional research on total knee arthroplasty (TKA) relies on preoperative patient-reported outcome measures (PROMs) to predict postoperative satisfaction. We aim to identify distinct patient phenotypes among TKA candidates, and investigate their correlations with patient characteristics. Between 2017 and 2021, patients with primary knee cases at a metropolitan public hospital were enrolled in a clinical quality registry.
View Article and Find Full Text PDFDisease continuum centered on Parkinson's disease.
Eur Neuropsychopharmacol
January 2025
Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, China; Academy of Military Medical Sciences, 27 Taiping Road, Beijing 100850, China. Electronic address:
Parkinson's disease (PD), once viewed as a neurodegenerative disorder, is now increasingly recognized as part of a broader disease continuum, intricately linked to comorbidities across various organ systems. This study provides a snapshot of the disease continuum centered on PD, using a disease-wide association study (DWAS) involving 392,423 individuals-including 4,235 PD cases. This DWAS identifies disease clusters of PD comorbidities across the musculoskeletal, circulatory, digestive, and respiratory systems.
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