The carcinogenesis of the human cervical precancerous lesion,cervical carcinoma is known closely associated with human papillomavirus (HPV). The purpose of this article is to identify whether HSV and CMV play as co-factor role in the carcinogenesis. Eighty-one cases of various cervical lesions were analyzed by HPV6/11, HPV16/18 in situ hybridization. Meanwhile, HPV, HSV and CMV were determined in 103 cases of various cervical lesions. The results show that the distribution of positive hybridization signal was consistent with the distribution of Koilocytic cells in HE stain. Of these cervical specimens investigated, the positive rates of HPV16/18 and HPV6/11 using ISH were 51% and 64%, respectively,the infection rates of HPV16/18, HPV6/11, HSV and CMV using PCR were 21%,4% 23% and 0%, respectively. The co-operation effect of HPV and HSV occurred in the oncogenesis of human cervical carcinoma, and moreover, the cellular and molecular biological mechanisms were discussed.
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