The work done in the Department of Biochemistry in Oxford during World War II is recounted. Reference is made to the research on burns, nutrition and malaria, but it is mainly concerned with the search for antidotes to mustard gas and lewisite. The discovery of a successful antidote to lewisite is described in some detail.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1098/rsnr.2005.0083 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Review: A systematic review of dairy cow health, welfare, and behaviour in year-round loose range housing.
Animal
December 2024
Oxford Systematic Reviews, 266 Banbury Road, Oxford, OX2 7DL, UK; Department of Biology, University of Oxford, Mansfield Road, Oxford, OX1 3SZ, UK.
This systematic review compares the health, welfare, and behaviour of dairy cows in year-round loose housing systems against those kept in other housing systems in temperate regions. Year-round loose housing systems comprised housing where dairy cows had no access to the outdoors or only had access to a yard, pen or run. The comparator housing systems also comprised housing with and without outdoor access (including grazing).
View Article and Find Full Text PDFP-P Coupling and Terminal Metal-Phosphorus Intermediates.
J Am Chem Soc
January 2025
Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Terminal metal-phosphorus (M-P) complexes are of significant contemporary interest as potential platforms for P-atom transfer (PAT) chemistry. Decarbonylation of metal-phosphaethynolate (M-PCO) complexes has emerged as a general synthetic approach to terminal M-P complexes. M-P complexes that are stabilized by strong M-P multiple bonds are kinetically persistent and isolable.
View Article and Find Full Text PDFPermissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis.
bioRxiv
January 2025
Nuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Autoimmunity affects 10% of the population. Within this umbrella, autoantibody-mediated diseases targeting one autoantigen provide a unique opportunity to comprehensively understand the developmental pathway of disease-causing B cells and autoantibodies. While such autoreactivities are believed to be generated during germinal centre reactions, the roles of earlier immune checkpoints in autoantigen-specific B cell tolerance are poorly understood.
View Article and Find Full Text PDFGenomic analysis of the main epidemiological lineages of in Mexico.
Front Cell Infect Microbiol
January 2025
Centro de Investigación Sobre Enfermedades Infecciosas (CISEI), Departamento de Diagnóstico Epidemiológico, Instituto Nacional de Salud Pública (INSP), Cuernavaca, Mexico.
has emerged as a critical global health threat due to its exceptional survival skills in adverse environment and its ability to acquire antibiotic resistance, presenting significant challenges for infection treatment and control. The World Health Organization has classified carbapenem-resistant as a "Critical Priority" pathogen to guide research and the development of control and prevention strategies. Epidemiological surveillance methodologies provide the tools necessary for classifying into international clonal lineages, facilitating the analysis of molecular characteristics, global dissemination, and evolution.
View Article and Find Full Text PDFMultiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes.
Brain
January 2025
Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, W1W 7FF, UK.
Prions are assemblies of misfolded prion protein that cause several fatal and transmissible neurodegenerative diseases, with the most common phenotype in humans being sporadic Creutzfeldt-Jakob disease (sCJD). Aside from variation of the prion protein itself, molecular risk factors are not well understood. Prion and prion-like mechanisms are thought to underpin common neurodegenerative disorders meaning that the elucidation of mechanisms could have broad relevance.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!