DNA strand scission is produced by the ambient light photolysis of CpFe(CO)(2)Ph and H(2)O(2), a result that shows potential as a means of targeting tumors, due to the high levels of hydrogen peroxide in cancer cells. This cleavage process is dependent on the concentration of both CpFe(CO)(2)Ph and H(2)O(2), and preliminary experiments implicate both carbon-centered radicals and reactive oxygen species.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2005.06.102 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Staining and External Bleaching on the Color Stability and Surface Roughness of Universal-Shade Resin-Based Composite.
Clin Cosmet Investig Dent
January 2025
College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Aim: This study evaluated the color stability and surface roughness of two universal-shade compared to two nanohybrid composites after staining and external bleaching with 40% hydrogen peroxide.
Methods: Two universal shade resin-based composites and two nanohybrid composites were tested. Twenty disc-shaped specimens from each material were fabricated and divided into two subgroups: one group was stained and bleached (staining group) and the other received bleaching treatment only (control group).
Imatinib mesylate promotes melanogenesis through the modulation of p38 and MITF in murine cells.
Toxicol Res
January 2025
Department of Applied Chemistry, Dong-Eui University, Busan, 614-714 Republic of Korea.
Imatinib mesylate is a targeted anti-cancer drug with skin pigmentation as a side effect. The action mechanism of imatinib mesylate on melanogenesis remains unclear. The purpose of this study was to elucidate the mechanism of imatinib mesylate on melanogenesis associated with the microphthalmia-associated transcription factor (MITF) signaling pathway in murine melanoma cells.
View Article and Find Full Text PDFEnhanced Electrocatalytic Hydrogen Peroxide Production via a CuWO/WO Heterojunction with High Selectivity and Stability.
ACS Appl Mater Interfaces
January 2025
Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
The electrocatalytic conversion of oxygen to hydrogen peroxide offers a promising pathway for sustainable energy production. However, the development of catalysts that are highly active, stable, and cost-effective for hydrogen peroxide synthesis remains a significant challenge. In this study, a novel polyacid-based metal-organic coordination compound (Cu-PW) was synthesized using a hydrothermal approach.
View Article and Find Full Text PDFElectrochemical Detection of Hydrogen Peroxide at High Concentrations Using Hastelloy G35 Electrode.
Langmuir
January 2025
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022, P R China.
The detection of hydrogen peroxide (HO) at elevated concentrations while eliminating oxygen interference presents a significant challenge. Nickel-based stainless steel, such as Hastelloy G35, has shown excellent corrosion resistance. However, it has never been used in electroanalysis.
View Article and Find Full Text PDFLigand engineering boosts catalase-like activity of gold nanoclusters for cascade reactions combined with glucose oxidase in ZIF-8 matrix.
Anal Chim Acta
February 2025
Tianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, Henan International Joint Laboratory of Tumor Theranostic Cluster Materials, Henan Key Laboratory of Crystalline Molecular Functional Materials, College of Chemistry, Zhengzhou University, 450001, Zhengzhou, China. Electronic address:
Background: Integrating natural enzymes and nanomaterials exhibiting tailored enzyme-like activities is an effective strategy for the application of cascade reactions. It is essential to develop a highly efficient and robust glucose oxidase-catalase (GOx-CAT) cascade system featuring controllable enzyme activity, a reliable supply of oxygen, and improved stability for glucose depletion in cancer starvation therapy. However, the ambiguous relationship between structure and performance, and the difficulty in controlling enzyme-mimic activity, significantly hinder their broader application.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!