AI Article Synopsis
- The study used an RNase protection assay to measure mRNA levels for ciliary neurotrophic factor (CNTF) in both normal and injured sciatic nerves.
- CNTF mRNA levels sharply decrease in the distal nerve stump within three days of nerve transection, dropping to less than 10% of normal levels after a week and staying low if regeneration does not take place.
- In injured peripheral nerves, the production of CNTF declines in areas where nerve growth factor (NGF) synthesis is heightened.
Article Abstract
The mRNA for ciliary neurotrophic factor in normal and injured sciatic nerves has been assayed by an RNase protection assay. The endoneurial concentration of ciliary neurotrophic factor mRNA is diminished in the distal nerve stump within three days of sciatic nerve transection, is less than one tenth of normal after one week, and remains low if regeneration does not occur. The synthesis of ciliary neurotrophic factor in injured peripheral nerves is decreased when and where the synthesis of nerve growth factor is increased.
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| http://dx.doi.org/10.1016/0006-8993(92)90489-v | DOI Listing |
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