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Bone marrow sympathetic neuropathy is a hallmark of hematopoietic malignancies and it involves severe ultrastructural damage.
Exp Hematol Oncol
March 2025
Stem Cells, Ageing and Cancer Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, MH2 Building Level 10, 9019, Tromsø, Norway.
The hematopoietic stem cell (HSC) niche in the bone marrow (BM) supports HSC function, fate and numbers [1]. Sympathetic fibres innervate the BM and are components of the hematopoietic stem and progenitor cell (HSPC) niche [2]. Neuropathy of the HSPC niche is present and essential for disease development in experimental models of JAK2 myeloproliferative neoplasms (MPN) and MLL-AF9 acute myeloid leukemia (AML), and it is present in the BM of human MPN and AML patients [3-6].
View Article and Find Full Text PDFFrequency of JAK2V617F Mutation Zygosity and Impact on Disease Outcome in MPN Patients.
Asian Pac J Cancer Prev
February 2025
Department of Molecular Biology, The National Center of Hematology, Mustansiriyah University, Baghdad 10015, Iraq.
Background: Myeloproliferative Neoplasm (MPN) is a clonal disorder of blood progenitor cells during haematopoiesis. JAK2V617F mutation represents one of the major identified genetic reasons of MPN disorder. It has been shown that JAK2V617F zygosity is associated with disease phenotype.
View Article and Find Full Text PDF[Predictive Value of Platelet Parameters for Arterial Complications in Patients with Myeloproliferative Neoplasms].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2025
School of Public Health, Capital Medical University, Beijing 100069, China.
Objective: To analyze the occurrence of arterial events and platelet parameters in patients with polycythemia vera (PV) and essential thrombocythemia (ET), and to explore the characteristics of platelet parameters in patients with PV and ET and their relationship with arterial complications.
Methods: The clinical and laboratory data of newly diagnosed PV and ET patients who visited the Department of Hematology, Beijing Anzhen Hospital, Capital Medical University from August 2017 to August 2022 were retrospectively analyzed.
Results: 86 MPN patients (46 males and 40 females) were enrolled, including 44 PV patients and 42 ET patients, with an median age of 61(23-83) years.
Background: Polycythemia vera (PV) and chronic lymphocytic leukemia (CLL) are distinct hematological malignancies. While their coexistence is rare, it poses unique diagnostic and therapeutic challenges.
Methods: A 50-year-old male patient presented with elevated hemoglobin levels and a marked lymphocytosis.
Thrombosis at Unusual Sites: Focus on Myeloproliferative Neoplasms and Paroxysmal Nocturnal Hemoglobinuria.
Hamostaseologie
February 2025
Department of Medicine (Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation), Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Patients with thrombosis at an unusual site will need to be explored for rare causes of thrombosis. Two of these rare causes include myeloproliferative neoplasms (MPNs) and paroxysmal nocturnal hemoglobinuria (PNH). It is important not to overlook these causes, since they require specific management, in addition to antithrombotic treatment (anticoagulants, antiplatelet agents).
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