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Prevalence and factors associated with sensitivity to methylisothiazolinone in individuals with suspected allergic contact dermatitis: A cross-sectional study.
Rev Alerg Mex
December 2024
Escola Superior de Ciências da Saúde ESCS Brasília/DF Brazil, Allergy and Dermatology Outpatient Unit at the Hospital Regional da Asa Norte HRAN - SMHN Q 2.
Objectives: To evaluate the prevalence of methylisothiazolinone sensitivity and associated factors in individuals with suspected allergic contact dermatitis.
Methods: Cross-sectional study based on patch tests, including methylisothiazolinone 0.2%, in 286 participants with suspected allergic contact dermatitis, in Brasília/DF, Brazil, between March/2020 and March/2022.
Understanding the impact of spatial immunophenotypes on the survival of endometrial cancer patients through the ProMisE classification.
Cancer Immunol Immunother
January 2025
Department of Obstetrics and Gynecology, Graduate School of Medicine, Nagoya University, 65, Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8560, Japan.
Objectives: We focused on how the immunophenotypes based on the distribution of CD8-positive tumor-infiltrating lymphocytes (TILs) relate to the endometrial cancer (EC) molecular subtypes and patients' prognosis.
Patients And Methods: Two cohorts of EC patients (total n = 145) were analyzed and categorized using the Molecular Risk Classifier for Endometrial cancer (ProMisE): POLEmut (POLE mutation), MMRd (mismatch repair deficiency), NSMP (no specific molecular profile), and p53abn (p53 abnormality). CD8-positive TILs, within the central tumor and the invasive margin, were examined by using immunohistochemical staining and advanced image-analysis software.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
The Neuroscience Institute at JFK Medical Center, Edison, NJ, USA; Hackensack Meridian School of Medicine, Nutley, NJ, USA.
Background: Disease-associated microglia (DAM), which cluster around Aβ plaques, represent a significant pathological hallmark of Alzheimer's disease (AD) and play a complex role in influencing neuroinflammation, mediating synapse loss, and participating in the phagocytic clearance of Aβ. Nonetheless, the precise mechanisms by which microglial activation extends beyond the traditional M1 and M2 classifications, encompassing a diverse spectrum of states, especially for DAM, closely intertwined with physiological and pathological conditions under Alzheimer's circumstances remain elusive.
Method: Here, we first combined biochemical techniques and bioinformatic analysis to test and quantify the expression of GABAR1 in both human and mouse AD models.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Department of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Background: Alzheimer's disease (AD) is a progressive irreversible dementia characterized by beta-amyloid protein plaque deposition and hyperphosphorylation of tau forming neurofibrillary tangles, and neurodegeneration. An emerging theory posits that infections could be one of the triggering factors in AD development and progression. Multiple lines of evidence have linked Chlamydia pneumoniae (Cp), a gram-negative obligate intracellular bacterium with AD.
View Article and Find Full Text PDF[Contact dermatitis in children].
Ugeskr Laeger
December 2024
Hudafdeling I og Allergicentret, Odense Universitetshospital.
Contact dermatitis is a common skin condition in children caused by environmental exposure to irritants or allergens. Manifestation of common endogenous eczemas, e.g.
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