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Oral Biomimetic Nanotherapeutics for Ulcerative Colitis Targeted Treatment by Repairing Intestinal Epithelial Barrier and Restoring Redox Homeostasis.
ACS Appl Mater Interfaces
January 2025
Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli South Street, Yinchuan 750004, PR China.
The structural disruption of intestinal barrier and excessive reactive oxygen/nitrogen species (RONS) generation are two intertwined factors that drive the occurrence and development of ulcerative colitis (UC). Synchronously restoring the intestinal barrier and mitigating excess RONS is a promising strategy for UC management, but its treatment outcomes are still hindered by low drug accumulation and retention in colonic lesions. Inspired by intestine colonizing bacterium, we developed a mucoadhesive probiotic -mimic entinostat-loaded hollow mesopores prussian blue (HMPB) nanotherapeutic (AM@HMPB@E) for UC-targeted therapy via repairing intestinal barrier and scavenging RONS.
View Article and Find Full Text PDFCharacteristics of gut microbiota dysbiosis in patients with colorectal polyps.
World J Gastrointest Oncol
January 2025
School of Life Health Information Science and Engineering, Chongqing Post and Communications University, Chongqing 400065, China.
This editorial, inspired by a recent study published in the , covers the research findings on microbiota changes in various diseases. In recurrent colorectal polyps, the abundances of , , and increase, while those of and decrease. This dysbiosis may promote the formation and recurrence of polyps.
View Article and Find Full Text PDFEvaluation of Probiotic Effects on the Growth Performance and Microbiome of Nile Tilapia () in a High-Density Biofloc System.
Aquac Nutr
January 2025
School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, Alabama 36849, USA.
Biofloc technology is an aquaculture production system that has gained popularity with tilapia production. Probiotics provide benefits for the host and/or aquatic environments by both regulating and modulating microbial communities and their metabolites. When a probiotic feed is combined with a biofloc system, the production amount may be improved through better fish growth, disease resistance, and/or improved water quality by reducing organic matter and stabilizing metrics such as pH and components of the nitrogen cycle.
View Article and Find Full Text PDFPrecision Psychobiotics for Gut-Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy.
Microb Biotechnol
January 2025
Fonterra Microbiome Research Centre, University College Cork, Cork, Ireland.
Advancing microbiome-gut-brain axis science requires systematic, rational and translational approaches to bridge the critical knowledge gaps currently preventing full exploitation of the gut microbiome as a tractable therapeutic target for gastrointestinal, mental and brain health. Current research is still marked by many open questions that undermine widespread application to humans. For example, the lack of mechanistic understanding of probiotic effects means it remains unclear why even apparently closely related strains exhibit different effects in vivo.
View Article and Find Full Text PDFAcne vulgaris: advances in pathogenesis and prevention strategies.
Eur J Clin Microbiol Infect Dis
January 2025
College of Food Science, Southwest University, Chongqing, China.
Purpose: The aim is to encourage the creation of innovative prevention and treatment measures and to help readers in selecting the most effective ones.
Background: Acne vulgaris is the most prevalent skin condition of adolescents, affecting approximately 9% of the global population. Patients become more prone to mental and psychological problems because of it.
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