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Cognitive Trajectory Before and After Cataract Surgery: A Population-Based Approach.
J Am Geriatr Soc
January 2025
Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California, USA.
Background: Cataract surgery is the most common surgical procedure performed for older US adults. Cataracts are associated with poor cognition and higher rates of dementia, but whether cataract surgery improves cognition for US older adults is not known. We examined the relationship between cataract surgery and long-term change in cognition in the Health and Retirement Study, a population-based study of older US adults linked with Medicare billing data.
View Article and Find Full Text PDFAssociation of antidepressants with cataracts and glaucoma: a disproportionality analysis using the reports to the United States Food and Drug Administration Adverse Event Reporting System (FAERS) pharmacovigilance database.
CNS Spectr
January 2025
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Article Synopsis
- Antidepressants, particularly Tricyclics (TCAs) and some new treatments, may increase the risk of cataracts, while others like Tetracyclics (TeCAs) and Monoamine Oxidase Inhibitors (MAOIs) appear to lower that risk.
- Several types of antidepressants, including SSRIs and SNRIs, have been linked to an increased risk of glaucoma, with risk ratios (RORs) showing significant associations.
- However, the study is limited by potential duplicate reports in the FDA database, and causality can't be definitively established. Overall, most antidepressants investigated were linked to lower cataract risk, but caution is needed in interpreting these findings
Invisible but Insidious Effects of Microplastics.
Molecules
December 2024
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.
Increasing evidence on the adverse health impacts of microplastics (MPs) is available, but their associated risks to the well-being of humans and long-term impacts are poorly understood. An indicator of the remote effects of MPs may be their influence on the rate of aging. To assess the effects of MPs on the aging process, we used accelerated senescence OXYS rats that develop a complex of geriatric diseases.
View Article and Find Full Text PDFEarly exposure to Western Diet exacerbates visual outcomes in female mice.
bioRxiv
December 2024
Laboratory of Neurovascular Control of Homeostasis, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
Obesity, a growing pandemic in Western societies, significantly impacts metabolic health and contributes to visual disorders. While the systemic consequences of obesity, such as chronic inflammation and insulin resistance, are well-studied in adults, its early-life effects on retinal health remain underexplored. Using a maternal Western Diet (WD) exposure model, we investigated the developmental impact of early-life metabolic disturbances on retinal and cognitive function.
View Article and Find Full Text PDFFrailty and Visual Impairment in Elderly Individuals: Improving Outcomes and Modulating Cognitive Decline Through Collaborative Care Between Geriatricians and Ophthalmologists.
Diseases
November 2024
Department of Medicine and HIV Metabolic Clinic, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes MK6 5LD, UK.
Article Synopsis
- - The increase in life expectancy is leading to higher rates of frailty and eye diseases in the elderly, with conditions like cataracts and glaucoma being particularly impactful, resulting in visual impairment that affects daily living and mental health.
- - Visual impairment due to eye diseases is closely linked to cognitive decline, creating a vicious cycle where reduced sensory input worsens cognitive health, leading to issues like depression and social isolation.
- - The review emphasizes the need for early intervention and interdisciplinary care to manage eye diseases and their cognitive implications in the elderly, highlighting the critical role of ophthalmologists in these efforts.
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