Rapidly developing optic neuritis secondary to ethambutol: possible mechanism of injury.

J Pak Med Assoc

Section of Neurology, Department of Medicine, Aga Khan University, Karachi.

Published: July 2005

AI Article Synopsis

  • Ethambutol can cause optic neuritis as a toxic side effect that is linked to the dosage taken.
  • The average duration for optic neuritis caused by Ethambutol is three months.
  • A specific case showed optic neuritis occurring after just a few days of Ethambutol use, with symptoms resolving after stopping the medication, indicating a possible unique reaction rather than a standard dose-related issue.

Article Abstract

Optic neuritis has been described among the toxic effects of Ethambutol. This side effect is dose related. The mean duration of Ethambutol induced optic neuritis (EON) is three months. We report a case of EON after few days of exposure to Ethambutol and the symptoms resolved after discontinuation of Ethambutol. This most likely represents an idiosyncratic reaction which is different as compared to dose related optic neuritis.

Download full-text PDF

Source

Publication Analysis

Top Keywords

optic neuritis
16
ethambutol
5
rapidly developing
4
optic
4
developing optic
4
neuritis
4
neuritis secondary
4
secondary ethambutol
4
ethambutol mechanism
4
mechanism injury
4

Similar Publications

Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.

Neurol Neuroimmunol Neuroinflamm

March 2025

Hospices Civils de Lyon, Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation-Hôpital Neurologique Pierre Wertheimer, Bron Cedex.

Objectives: To characterize the serum cytokine profile in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at onset and during follow-up and assess their utility for predicting relapses and disability.

Methods: This retrospective multicentric cohort study included patients aged 16 years and older meeting MOGAD 2023 criteria, with serum samples collected at baseline (≤3 months from disease onset) and follow-up (≥6 months from the baseline), and age-matched and time to sampling-matched patients with multiple sclerosis (MS). Eleven cytokines were assessed using the ELLA system.

View Article and Find Full Text PDF

Basic Science and Pathogenesis.

Alzheimers Dement

December 2024

Brown University, Providence, RI, USA.

Background: Chitinase-3-like protein 1 (CHI3L1, or YKL-40) is an important regulator of immunity and, in the brain, is primarily secreted by activated astrocytes and heralds a neurotoxic inflammatory state. While it has been well known as a high-profile biomarker for Alzheimer's disease (AD) and inflammatory brain conditions (e.g.

View Article and Find Full Text PDF

We present a rare case of optic neuropathy due to anaplastic lymphoma kinase-positive (ALK+) anaplastic large cell lymphoma (ALCL) with optic nerve infiltration in a 12-year-old girl who presented with acute unilateral vision loss, diplopia, and headache after two prior hospitalizations at an outside facility for disk edema. She had a presumptive diagnosis of neurosarcoidosis and empiric treatment had been initiated with high-dose corticosteroids. Ongoing worsening of vision prompted presentation at our facility.

View Article and Find Full Text PDF

Intracranial Hypertension (ICHT) is identified as the elevation of Cerebrospinal Fluid (CSF) pressure in patients devoid of any underlying causes. Optic Neuritis (ON) is not typically seen as a complication of ICHT, and patients diagnosed with concurrent manifestation of both these disorders usually have some identifiable underlying cause. In this report, we highlight the clinical and para-clinical findings in two unrelated children presenting with high CSF opening pressures and Optic neuritis in the absence of any identifiable neurological or immunological cause.

View Article and Find Full Text PDF

Optic neuritis (ON) is defined as an acquired disorder of the optic nerve that may be associated with demyelinating diseases or infectious or inflammatory processes. In children, the manifestation of this condition differs from that in adults, where it typically presents with bilateral papillitis subsequent to a preceding viral illness. Nonetheless, the main concern for practitioners is the possibility of its conversion to multiple sclerosis (MS).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!