Objective: To select the receptor fluid used in the in-vitro skin permeation study of CVD from Shuxin transdermal patch.
Methods: The saturated concentration of CVD in different receptor fluid was determined by RP-HPLC with precolumn ultraviolet derivatization. And the selection of receptor fluid was based on main drug's dissolvability.
Results: The concentration of CVD in 30% ethanol/physiological saline was the highest among seven kinds of receptor fluid.
Conclusion: The method used to select the receptor fluid based on main drug's dissolvability in the in-vitro skin permeation study is credible and convenient.
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