Antioxidative and antiradical properties of a new antioxidant cerebroprotective drug, enoxifol (benzimidasole derivative), were compared with mexidol by means of three chemiluminescent techniques: luminol autooxidation system, Fe2+-induced lipid chemiluminescence and lucigenin-induced chemiluminescence with superoxide generation by xanthine-xanthine oxidase system. Enoxifol exhibited higher antiradical activity than mexidol. This was shown by suppression of luminol radicals and superoxide anion-radical generation. Antioxidant properties of enoxifol were also demonstrated by decreasing of Fe2+-induced lipid chemiluminescence. The recognized properties of enoxifol influencing chemiluminescent processes confirm the results, obtained earlier by means of indirect methods of free radical processes study in vitro and in vivo (decrease of LPO products, activation of antioxidant enzymes), also can underline its pharmacological effects.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Kombucha fortified with Cascade hops (Humulus lupulus L.): enhanced antioxidative and sensory properties.
Appl Microbiol Biotechnol
January 2025
Faculty of Biotechnology and Food Sciences, Institute of Fermentation Technology and Microbiology, Lodz University of Technology, Wolczanska 171/173, 90-530, Lodz, Poland.
In recent years, there has been a surge in the production of kombucha-a functional beverage obtained via microbial fermentation of tea. However, fresh, unpasteurized kombucha is sensitive to quality deterioration as a result of, among other factors, oxidation. The addition of hops seems to be promising, due to their antioxidative properties, which may improve the stability of kombucha.
View Article and Find Full Text PDFThe Effect of β-Glucan on the Release and Antiradical Activity of Phenolic Compounds from Apples in Simulated Digestion.
Molecules
January 2025
Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhaca 18, 31000 Osijek, Croatia.
Beneficial activities of phenolic compounds in the gastrointestinal tract, such as antiradical activity, are affected by the food matrix. The aim of this study was to investigate the influence of one constituent of the food matrix (dietary fiber β-glucan) on the release and antiradical activity of phenolic compounds from apples in gastrointestinal digestion. Simulated digestion in vitro was conducted on whole apples without or with added β-glucan.
View Article and Find Full Text PDFBiological and Health-Promoting Potential of Fruits from Three Cold-Hardy Actinidia Species.
Molecules
January 2025
REQUIMTE/LAQV, ISEP, Polytechnic of Porto, Rua Dr. António Bernardino de Almeida, 431, 4200-072 Porto, Portugal.
Fruits are essential components of the human diet, valued for their diverse bioactive compounds with potential health-promoting properties. This study focuses on three cold-hardy species, namely , , and , examining their polyphenolic content, antioxidant/antiradical activities, scavenging capacity and effects on intestinal cell viability (Caco-2 and HT29-MTX). A comprehensive profile of their phenolic compounds was identified, in descending order of total polyphenol content: > > .
View Article and Find Full Text PDFStarch-Assisted Eco-Friendly Synthesis of ZnO Nanoparticles: Enhanced Photocatalytic, Supercapacitive, and UV-Driven Antioxidant Properties with Low Cytotoxic Effects.
Int J Mol Sci
January 2025
Department of Mathematical, Physical and Computer Sciences, University of Parma, 43124 Parma, Italy.
This study presents an efficient and environmentally sustainable synthesis of ZnO nanoparticles using a starch-mediated sol-gel approach. This method yields crystalline mesoporous ZnO NPs with a hexagonal wurtzite structure. The synthesized nanoparticles demonstrated remarkable multifunctionality across three critical applications.
View Article and Find Full Text PDFPomegranate Juices: Analytical and Bio-Toxicological Comparison of Pasteurization and High-Pressure Processing in the Development of Healthy Products.
Foods
January 2025
Department of Chemistry and Technologies of Drug, "Sapienza" University of Rome, 00185 Rome, Italy.
Two different produced and packaged commercial typologies of pomegranate juice were analyzed for their physicochemical, nutritional, and biological properties. The effects of classical pasteurization (PJ) and high-pressure processing (HP), applied during the productive cycle, were evaluated through several advanced analytical methods, such as CIEL*a*b* colorimetry, HPLC-DAD, DI-ESI-MS and MS/MS, and NMR analyses. Moreover, the exerted biological activity of the two pomegranate juices was monitored through Total Phenolic and Total Flavonoid Contents, antiradical, antioxidant and chelating activity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!