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Melatonin promotes the proliferation and differentiation of antler chondrocytes via RUNX2 dependent on the interaction between NOTCH1 and SHH signaling pathways.
Cell Biol Int
December 2024
College of Veterinary Medicine, Jilin University, Changchun, China.
Melatonin (MT), an endogenous hormone secreted by pineal gland, has the sedative, anti-inflammatory and antioxidant functions. However, there are few studies on whether MT affects the proliferation and differentiation of antler chondrocytes. The present study investigated the influences of MT on the proliferation and differentiation of antler chondrocytes, explored its regulation on runt-related transcription factor 2 (RUNX2), NOTCH1 and sonic hedgehog (SHH) signaling, and elucidated their interplays.
View Article and Find Full Text PDFLeveraging Single Nucleotide Polymorphism Profiling for Precision Skin Care: How SNPs Shape Individual Responses in Cosmetic Dermatology.
J Cosmet Dermatol
January 2025
Centre Médical Laser Palaiseau, Palaiseau, France.
Introduction: Single-nucleotide polymorphisms (SNPs) represent a significant genetic variation influencing individual responses to cosmetic dermatology treatments. SNP profiling offers a pathway to personalized skincare by enabling practitioners to predict patient outcomes, customize interventions, and mitigate risks.
Background: The integration of genetic insights into dermatology has gained traction, with SNP analysis revealing predispositions in skin characteristics, such as collagen degradation, pigmentation, and inflammatory responses.
Methyltransferase-like 14 promotes the tumorigenesis and proliferation of pancreatic cancer cells through myc proto-oncogene signaling pathway.
Cytojournal
November 2024
Department of General Surgery, Jincheng General Hospital, Jincheng, China.
Objective: Pancreatic cancer is characterized by low survival rate and rapid deterioration. Methyltransferase-like 14 (METTL14), as N6-methyladenosine (m6A) methyltransferase, is closely related to tumor progression. The purpose of this study is to look into how METTL14 affects pancreatic cancer tumorigenesis, cell division, and apoptosis.
View Article and Find Full Text PDFInhibition of lysine-specific histone demethylase 1A suppresses adenomyosis through reduction in ectopic endometrial stromal cell proliferation, migration, and invasion.
Cytojournal
November 2024
Department of Gynecology , Qingdao Women and Children's Hospital, Shandong University, Qingdao, China.
Objective: Deep endometriosis is now referred to as adenomyosis externa, whereas adenomyosis is once known as endometriosis interna. Lysine-specific histone demethylase 1A (KDM1A, commonly LSD1) is a lysine demethylase that targets histone and non-histone proteins. This study aimed to assess how KDM1A affects the migration, invasion, and proliferation of adenomyosis-derived endometrial stromal cells (ESCs).
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