AI Article Synopsis
- The study evaluated how social isolation versus crowding affects female mice's behavior after they received single or repeated doses of ethanol.
- While single ethanol doses increased movement regardless of housing conditions, repeated doses caused greater sensitivity in crowded mice compared to those isolated or in control conditions.
- Social isolation reduced the negative impact of ethanol on behavior (like increased immobility) and promoted tolerance to some effects, indicating that living conditions significantly influence how ethanol affects behavior.
Article Abstract
The differential outcomes of social isolation and crowding environment on the effects of single or repeated administration of ethanol on open-field behavior were examined in female mice. Whereas housing conditions did not alter the increase in locomotor activity induced by ethanol single administration, behavioral sensitization (a progressive increase of a drug effect following repeated drug administration) to the locomotor activating effect of ethanol was significantly greater in crowded mice as compared to isolated and control groups. Single administration of ethanol significantly decreased rearing frequency and increased immobility duration, there being tolerance to these ethanol behavior effects after repeated treatment. Social isolation attenuated the increase in immobility behavior induced by single administration of ethanol and potentiated the tolerance of ethanol-induced rearing decrease, verified after repeated treatment. These results point out that both sensitization and tolerance to the behavioral effects of ethanol can be critically influenced by housing conditions.
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| http://dx.doi.org/10.1016/j.pbb.2005.07.009 | DOI Listing |
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