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Impact of endoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) on neutrophil cellular functions.
Front Cell Dev Biol
January 2025
Dipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, Milano, Italy.
Introduction: Endoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) modulate a plethora of physiological processes for the maintenance of homeostasis in different cellular subsets at both intra and extracellular level.
Materials And Methods: In this frame, the extracellular supplementation of recombinant human (rh) ERAP1 and ERAP2 (300 ng/ml) was used to mimic the effect of stressor-induced secretion of ERAPs on neutrophils isolated from 5 healthy subjects. In these cells following 3 h or 24 h rhERAP stimulation by Western Blot, RT-qPCR, Elisa, Confocal microscopy, transwell migration assay, Oxygraphy and Flow Cytometry we assessed: i) rhERAP internalization; ii) activation; iii) migration; iv) oxygen consumption rate; v) reactive oxygen species (ROS) accumulation; granule release; vi) phagocytosis; and vii) autophagy.
Anterior Controllable Antedisplacement Fusion (ACAF) in Revision Surgery for Iatrogenic Cervical Kyphosis: Technical Note and Case Series.
Orthop Surg
January 2025
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Background: Iatrogenic cervical kyphosis (ICK) often requires complex anterior and posterior correction, which is associated with multiple complications. Consequently, there is a need to investigate alternative treatment approaches that streamline the operative process and markedly diminish postoperative complications. This study, therefore, aimed to evaluate the feasibility and efficacy of a single-stage anterior controllable antedisplacement fusion (ACAF) in revision surgeries for ICK.
View Article and Find Full Text PDFEffect of oat β-glucan on the freezing resistance of yeast and the underlying mechanism.
Int J Biol Macromol
January 2025
College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, China; Key Laboratory of Staple Grain Processing, Ministry of Agriculture and Rural Affairs, Zhengzhou 450002, China. Electronic address:
The objective of this study was to investigate the protective effects of oat β-glucan (OβG) on yeast subjected to freeze-thaw cycle-induced stress. A range of analytical techniques were employed to identify the underlying molecular mechanisms, including flow cytometry, gas chromatography-mass spectrometry, and quantitative real-time PCR. Following three freeze-thaw cycles, the survival rate of yeast that had been supplemented with 0.
View Article and Find Full Text PDFA 77-year-old man was referred to our department because of macrohematuria, oliguria, and a serum creatinine level of 2.47 mg/dL during boron neutron capture therapy (BNCT) for oropharyngeal cancer. At baseline, his creatinine level had been 0.
View Article and Find Full Text PDFAbnormalities in mitochondrial energy metabolism induced by cryopreservation negatively affect goat sperm motility.
Front Vet Sci
January 2025
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
The motility of sperm decreases following cryopreservation, which is closely associated with mitochondrial function. However, the alterations in mitochondrial metabolism after sperm freezing in goats remain unclear. This experiment aimed to investigate the impact of ultra-low temperature freezing on goat sperm's mitochondrial energy metabolism and its potential correlation with sperm motility.
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