Genistein has been shown to prevent bone loss in ovariectomized adult rats. However, the effects of genistein on bone in developing and reproductively-intact rats have not been examined. A large multigenerational experiment involved feeding 0, 5, 100, or 500 ppm genistein in the diet to intact male and female rats from conception until either weaning, postnatal day 140, or continuously for 2 years. Vertebrae (lumbar and caudal) were collected from these animals at necropsy at 2 years of age and subjected to dual-energy x-ray absorptiometry (DXA) scanning to measure bone mineral density (BMD), bone mineral content (BMC), and bone area. Femurs were collected, and length, cross-sectional area, and cortical bone area were measured directly. Serum was collected for measurement of pyridinoline (PYD) and alkaline phosphatase (ALP). BMD was not affected by genistein in any phase of the experiment. In female rats treated continuously with genistein, BMC and bone area were reduced in the 500 ppm group compared to the 5 ppm group in the lumbar vertebrae, and in all treatment groups compared to control in the caudal vertebrae. In both males and females treated continuously, the cross-sectional area of the femur was reduced in rats treated with 500 ppm compared to those treated with 5 ppm. In female rats treated continuously, PYD was higher in the 100 and 500 ppm groups than in the 0 and 5 ppm groups. In conclusion, the effects of genistein on reproductively-intact rats were not dramatic. High dose of genistein throughout the lifespan resulted in decreased bone size, which may reduce the force required to break the bone.
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http://dx.doi.org/10.1016/j.bone.2005.06.005 | DOI Listing |
Plants (Basel)
January 2025
Laboratorio de Fitopatología, Escuela de Agronomía, Facultad de Ciencias Agronómicas y de los Alimentos, Pontificia Universidad Católica de Valparaíso, Casilla 4-D, Quillota 2260000, Chile.
In Chile and worldwide, walnut () production faces significant losses due to crown and root rot caused by the phytopathogen . Currently, control methods have proven insufficient or unfavorable for the environment, increasing the need for sustainable alternatives. This research evaluates nanoemulsions based on extracts of medicinal plants endemic to Chile to control in walnut crops.
View Article and Find Full Text PDFMolecules
January 2025
Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
In recent years, the anti-corrosive properties of natural extracts as environmentally friendly inhibitors have gained considerable interest. This study evaluates the potential of ( L.) essential oil (), collected from Salé, Morocco, as a corrosion inhibitor for mild steel in 1 M HCl medium.
View Article and Find Full Text PDFPoult Sci
January 2025
Department of Food and Animal Sciences, Tennessee State University, Nashville, TN 37209, USA. Electronic address:
Poultry drinking water quality parameters influence physiological functions and bird health. This study aimed to explore the impacts of poultry drinking water pH, TDS (total dissolved solids), and elevated levels of certain minerals on the early phase of broiler performance. Four treatment groups were created based on water source and water quality types: i) municipal water source (MW); ii) well/underground water source with moderately higher levels of Ca, SO, and Mn (WW); iii) high-pH (>8) water (HPH); and iv) high-TDS water (>3000 ppm) (HTDS).
View Article and Find Full Text PDFHeliyon
January 2025
Department of Agronomy, Bangladesh Agricultural University, Mymensingh, 2202, Bangladesh.
Reducing the harmful chemical use along with obtaining potential yield in field is a worth exploring practice in rice cultivation. To mitigate the prevailing yield gap, the current study was designed to evaluate the effect of chitosan in improving growth, yield contributing characters and yield of rice. The experiment comprised eight different treatments control (no fertilizer and Chitosan) (T), conventional method (with fertilizers) (T), conventional method with foliar spray of 100 ppm chitosan solution (T), conventional method with foliar spray of 300 ppm chitosan solution (T), conventional method with foliar spray of 500 ppm chitosan solution (T), only foliar spray of 100 ppm chitosan solution (T), only foliar spray of 300 ppm chitosan solution (T), and only foliar spray of 500 ppm chitosan solution (T).
View Article and Find Full Text PDFMagn Reson Med
January 2025
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Purpose: To optimize a 100 ms pulse for producing CEST MRI contrast and evaluate in mice.
Methods: A gradient ascent algorithm was employed to generate a family of 100 point, 100 ms pulses for use in CEST pulse trains (proton resonance enhancement for CEST imaging and shift exchange). Gradient ascent optimizations were performed for exchange rates = 500, 1500, 2500, 3500, and 4500 s; and labile proton offsets (Δω) = 9.
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