Several authors have detailed the microscopic appearance of the acoustic neuroma/cochlear nerve interface. Others have highlighted the anatomic relationships existent between the lateral end of the internal auditory canal (fundus) and the otic capsule, as viewed from the posterior fossa. Based on these findings, several have suggested that hearing preservation attempts are likely associated with tumor persistence. They therefore question the feasibility of hearing preservation surgery. In this study, computerized tomography or magnetic resonance imaging was carried out on 28 patients having previously undergone excision of an acoustic neuroma with intraoperative sparing of the cochlear and facial nerves. Scans were done at least 5 years following surgery. Results of this study and a discussion of the literature follow.
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Brain Sci
January 2025
Department of Otolaryngology at Unfallkrankenhaus Berlin, Charité Medical School, University of Berlin, 12683 Berlin, Germany.
Background: Previous studies have shown that multiple post-traumatic irradiations of the cochlea with near-infrared light (NIR) can significantly reduce noise-induced hearing loss. However, a single NIR pre-treatment was shown to have the same effect. Extending the pre-treatment time did not result in any further reduction in hearing loss.
View Article and Find Full Text PDFRev Med Suisse
January 2025
Service d'oto-rhino-laryngologie et de chirurgie cervico-faciale, Centre hospitalier universitaire vaudois, 1011 Lausanne.
This article highlights recent advancements in otorhinolaryngology. It reviews innovations in managing sudden sensory-neural hearing loss through low-dose glucocorticoid treatments and explores pediatric audiology breakthroughs, particularly gene therapy for DFNB9 deafness. In speech pathology and oncology, a new minimally invasive robotic surgical approach enhances organ preservation for head and neck cancers.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.
Assembly of actin-based stereocilia is critical for cochlear hair cells to detect sound. To tune their mechanosensivity, stereocilia form bundles composed of graded rows of ascending height, necessitating the precise control of actin polymerization. Myosin 15 (MYO15A) drives hair bundle development by delivering critical proteins to growing stereocilia that regulate actin polymerization via an unknown mechanism.
View Article and Find Full Text PDFWorld Neurosurg
January 2025
Departments of Neurosurgery, Los Angeles, California, USA; Radiation Oncology, Los Angeles, California, USA; Head and Neck Surgery, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, Los Angeles, California, USA; Los Angeles Biomedical Research Institute, Los Angeles, California, USA; Harbor-UCLA Medical Center, Los Angeles, California, USA.
Mol Genet Metab Rep
March 2025
Department of Biochemistry, JSS Medical College and Hospital, JSS-AHER, Mysuru 570015, India.
Mitochondrial DNA (mtDNA) variants considerably affect diabetes mellitus by disturbing mitochondrial function, energy metabolism, oxidative stress response, and even insulin secretion. The m.3243 A > G variants is associated with maternally inherited diabetes and deafness (MIDD), where early onset diabetes and hearing loss are prominent features.
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