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Distinctive clinical features in biopsy-proven nerve large-arteriole vasculitis and microvasculitis.
Brain
December 2024
Department of Neurology, Mayo Clinic, Rochester, MN, 55905 USA.
Vasculitic neuropathy is caused by inflammatory destruction of nerve blood vessels resulting in nerve ischemia. Nerve vasculitis can be divided into two categories based on vessel size - large arteriole vasculitis (≥75 µm) and microvasculitis (<75 µm). Herein, we characterize the clinical features of nerve large-arteriole vasculitis compared to nerve microvasculitis.
View Article and Find Full Text PDFVasculitic Myopathy: Clinical Characteristics and Long-Term Outcomes.
Neurology
December 2024
From the Department of Neurology (M.V.P., P.S., E.N.), and Division of Rheumatology (K.J.W., M.J.K.), Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Article Synopsis
- - The study investigates vasculitic myopathy, a rare manifestation of vasculitis, to characterize its clinical features, lab results, and treatment outcomes using a retrospective review of patient records from 1980 to 2022.
- - Out of 25 identified patients, most presented with proximal weakness and pain, with 80% showing myopathy as the first sign of vasculitis; significant findings included inflammation in muscle biopsies and elevated blood markers in some cases.
- - Key findings include high instances of perivascular inflammation in biopsies, with substantial destruction noted in vessel walls; a notable proportion of patients also displayed signs of peripheral neuropathy.
Top 10 Clinical Pearls in Vasculitic Neuropathies.
Semin Neurol
September 2024
Department of Neurology, Virginia Commonwealth University, Richmond, Virginia.
Article Synopsis
- Vasculitic neuropathies are inflammatory conditions affecting the peripheral nerves, often caused by systemic vasculitis or related disorders, leading to painful sensory and motor deficits.
- Diagnosis involves extensive tests, including lab work, electrodiagnostics, and tissue biopsies, while treatment typically includes immunosuppressants and pain management.
- Timely recognition and intervention are crucial to prevent serious complications, including permanent nerve damage or fatal outcomes.
[Non-Eosinophilic Granulomatosis with Polyangiitis Vasculitic Neuropathy: An Overview].
Brain Nerve
May 2024
Department of Neurology, Aichi Medical University.
Vasculitic neuropathy is commonly associated with systemic vasculitis, leading to ischemic damage to the peripheral nerves and axonal degeneration. The typical clinical manifestation of vasculitic neuropathy is a sensory-dominant multiple mononeuropathy often accompanied by pain. Although vasculitic neuropathy is caused by various systemic diseases, ANCA-associated vasculitis, secondary systemic vasculitis linked to various collagen diseases, and non-systemic vasculitic neuropathy hold particular significance.
View Article and Find Full Text PDFFocal inflammatory neuropathies.
Handb Clin Neurol
May 2024
Division of Neuromuscular Medicine, Department of Neurology, Mayo Clinic, Rochester, MN, United States; Peripheral Neuropathy Research Laboratory, Mayo Clinic, Rochester, MN, United States. Electronic address:
Article Synopsis
- The chapter discusses neuropathies characterized by inflammation or autoimmune responses affecting specific nerve roots, plexuses, and peripheral nerves.
- It examines various types of focal autoimmune demyelinating neuropathies, vasculitic disorders, and other focal neuropathies related to conditions like diabetes and infections.
- Key points include the clinical presentations, diagnostic methods, and treatment options for these conditions.
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