In developed countries, adolescent death rate is under 1%, predominantly due to accidents. Amongst chronic diseases cancer has a prevalent role. A severe disease plays against the normal subjectivation and autonomization adolescent process. It leads to unbearable restrictions in being on the move with their mates, being proud of their body image, attending school. It increases parents' dependency and induces multiple treatment discomforts. Nursing team has to consider the adolescent as its primary interlocutor, to fulfil his demands of autonomy and to validate his choices, and to contribute to maintaining his links with his parents. Moreover, specific expressions of adolescent's needs in the field of pain control, body intimacy, information, schooling, sublimation's behaviours, sexuality, have to be recognized and satisfied.
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