AI Article Synopsis
- The study investigated heterotopic bone formation in 45 male Wistar rats by implanting varying amounts of demineralized bone powder (5, 10, or 15 mg) and evaluating the results at 4 weeks.
- The research focused on two indices for measuring 85Sr uptake, revealing that the osteoquantum index correlated strongly (r = 0.90) with the area of the newly formed bone, while the osteogenic index showed weak correlations (r = 0.32 for area and r = 0.33 with the osteoquantum index).
- It was concluded that the induced bone area and osteoquantum index both increased with higher amounts of DBM, while the osteogenic index
Article Abstract
Heterotopic bone formation in the abdominal muscle of 45 male 8-week-old Wistar rats induced by implantation of 5, 10, or 15 mg demineralized bone (DBM) powder was evaluated at 4 weeks by 85Sr uptake of the implants and area histomorphometry of the induced bone. Two indices of 85Sr uptake were calculated: the osteogenic index [(counts/min/mg implant)/(counts/min/mg os ilium)] and an index that we have called the osteoquantum index in which the weight of the implant is disregarded [(counts/min implant)/(counts/min/mg os ilium)]. The osteoquantum index showed a linear relationship to the area of the induced bone with a correlation coefficient (r) of 0.90. Only weak linear relationships were found between the osteogenic index and the area of the bone (r = 0.32) and between the osteogenic index and the osteoquantum index (r = 0.33). The osteoquantum index and the area of the induced bone both increased with increasing mass of implanted DBM, whereas the osteogenic index did not change.
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| http://dx.doi.org/10.3109/17453679209154795 | DOI Listing |
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