Results of optimization of general anesthesia during abdominal surgeries in patients with abdominal sepsis are analyzed. Inhibitors of proteases (transamin and antagozan) were used as non-opiate component in transduction stage. Central hemodynamics, gaseous metabolism and heart rate were analyzed in two groups of patients: group 1 -- anesthesia was carried out with inhibitors of proteases (32 patients), group 2 -- without it (30 patients). High efficacy of the inhibitors was demonstrated. Inhibitors of proteases are indicated for anesthesia in patients with severe metabolic disorders associated with tissues hypoxia. Analgesic activity of transamin permits one to decrease doses of anesthetic medication with a cardiodepressive effect.
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