The successful design of nanofluidic devices for the manipulation of biopolymers requires an understanding of how the predictions of soft condensed matter physics scale with device dimensions. Here we present measurements of DNA extended in nanochannels and show that below a critical width roughly twice the persistence length there is a crossover in the polymer physics.
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http://dx.doi.org/10.1103/PhysRevLett.94.196101 | DOI Listing |
Ying Yong Sheng Tai Xue Bao
October 2024
Shenyang Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China.
Quantitative evaluation of urban ecological carrying capacity is a critical foundation for measuring urban sustainable development in the new era. This review would enrich the concept and connotation of urban ecological carrying capacity by sorting out its components and characteristics. We categorized the methods for quantifying urban ecological carrying capacity into static evaluation methods, including ecological footprint method, comprehensive evaluation method, state space method, net primary productivity method, and carbon-oxygen balance method, as well as dynamic simulation prediction methods, including system dynamics models, BP neural network prediction models, and grey prediction models.
View Article and Find Full Text PDFJ Biomed Mater Res A
January 2025
Department of Pediatrics, All India Institute of Medical Sciences Rishikesh, Rishikesh, India.
Long-term electrocardiogram (ECG) monitoring is crucial for detecting and diagnosing cardiovascular diseases (CVDs). Monitoring cardiac health and activities using efficient, noninvasive, and cost-effective techniques such as ECG can be vital for the early detection of different CVDs. Wet electrode-based traditional ECG techniques come with unavoidable limitations of the altered quality of ECG signals caused by gel volatilization and unwanted noise followed by dermatitis.
View Article and Find Full Text PDFRev Sci Instrum
December 2024
College of Intelligent Manufacturing, Long Dong University, Qingyang, Gansu 745000, China.
The deflector jet pressure servo valve (DJPSV), a critical component of the aircraft brake servo system, requires a precise foundational model for performance analysis, optimization, and enhancement. However, the complexity of the jet process within the V-groove of the deflector plate presents challenges for accurate mathematical modeling. To address this issue, the paper takes the DJPSV as the research object, carries out detailed mathematical modeling of its components, analyzes the influencing factors of the performance of the key component-the front stage-and optimizes the design of the key factors.
View Article and Find Full Text PDFJ Antimicrob Chemother
December 2024
Department of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, Hamburg, Germany.
Background: MDR Gram-negative bacteria, such as ESBL-producing and carbapenemase-producing Klebsiella pneumoniae, represent major global health threats. Treatment options are limited due to increasing resistance and slowed development of novel antimicrobials, making it necessary to apply effective combination therapies based on approved antibiotics.
Objectives: To quantitatively evaluate the synergistic potential of meropenem and fosfomycin against carbapenem-resistant K.
Front Med (Lausanne)
December 2024
Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.
Background And Hypothesis: A static predictive model relying solely on baseline clinicopathological data cannot capture the heterogeneity in predictor trajectories observed in the progression of chronic kidney disease (CKD). To address this, we developed and validated a dynamic survival prediction model using longitudinal clinicopathological data to predict end-stage kidney disease (ESKD), with death as a competing risk.
Methods: We trained a sequence of random survival forests using a landmarking approach and optimized the model with a pre-specified prediction horizon of 5 years.
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