Many growing networks possess accelerating statistics where the number of links added with each new node is an increasing function of network size so the total number of links increases faster than linearly with network size. In particular, biological networks can display a quadratic growth in regulator number with genome size even while remaining sparsely connected. These features are mutually incompatible in standard treatments of network theory which typically require that every new network node possesses at least one connection. To model sparsely connected networks, we generalize existing approaches and add each new node with a probabilistic number of links to generate either accelerating, hyperaccelerating, or even decelerating network statistics in different regimes. Under preferential attachment for example, slowly accelerating networks display stationary scale-free statistics relatively independent of network size while more rapidly accelerating networks display a transition from scale-free to exponential statistics with network growth. Such transitions explain, for instance, the evolutionary record of single-celled organisms which display strict size and complexity limits.
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http://dx.doi.org/10.1103/PhysRevE.72.016123 | DOI Listing |
Naunyn Schmiedebergs Arch Pharmacol
January 2025
School of Pharmacy, RK University, Kasturbadham, Rajkot, Gujarat, 360020, India.
Hypertension, a prevalent cardiovascular condition affecting a substantial portion of the global population, remains a formidable health challenge associated with a multitude of complications. This review article provides a comprehensive examination of hypertension, its various complications, and the emergence of a novel management technique that shows promising potential in transforming the therapeutic landscape. Over the years, conventional treatment approaches, encompassing lifestyle modifications, dietary interventions, and pharmacotherapy, have been the mainstay in managing hypertension.
View Article and Find Full Text PDFOral Dis
January 2025
Primary Care/Health Sciences Postgraduate Program, State University of Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil.
Objective: To summarize the evidence on the relationship between hereditary family history and nonsyndromic orofacial clefts (NSOC) in patients from various Brazilian states.
Methods: This cross-sectional multicenter study was conducted at six specialized orofacial cleft services across different regions of Brazil. The sample consisted of 1899 patients with NSOC, including cleft lip only (NSCLO), cleft palate only (NSCPO), and cleft lip and palate (NSCLP).
Pharmacoepidemiol Drug Saf
February 2025
Netherlands Pharmacovigilance Centre Lareb, 's Hertogenbosch, Hertogenbosch, the Netherlands.
Background: Vitamin B6 deficiency is linked to neurological disorders. However, supplementation with high doses of vitamin B6 has also been linked to neuropathy as an adverse drug reaction. Review of cases from the Dutch Spontaneous Reporting System (SRS) and other data led to a regulatory action to lower the maximum daily dose (DD) of vitamin B6 in supplements to 21 mg/day from October 1, 2018.
View Article and Find Full Text PDFJ Oral Rehabil
January 2025
Department of Medical Biotechnologies, School of Dentistry, University of Siena, Siena, Italy.
Background: Despite the aetiology of awake bruxism (AB) being prevalently linked to psychological factors, several studies suggested that the use of certain substances, such as tobacco smoking, can contribute to the increase in masticatory muscle activities (MMA) during wakefulness.
Objective: The aim of this study is to assess whether there is a correlation between the frequency of awake bruxism behaviours and smoking habits.
Methods: Participants were recruited, without gender or ethnic restriction, at the University of Siena, Siena, Italy, by advertising.
Otolaryngol Head Neck Surg
January 2025
Department of Otolaryngology-Head and Neck Surgery, Houston Methodist Hospital, Houston, Texas, USA.
Objective: This study aims to assess whether private equity (PE) acquisitions of otolaryngology-head and neck surgery (OHNS) practices are associated with changes in Medicare payments and procedure volume.
Study Design: A cross-sectional study.
Setting: PitchBook and the Medicare Provider Utilization and Payment Data File.
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