The degradation of low energy electrons in a methane based, tissue equivalent gas was studied experimentally by ionization chamber experiments and theoretically by Monte Carlo electron transport simulation in the energy range between 25 eV and 5 keV. From measured ionization yields and calculated ionization and energy dissipation profiles, the mean energy W required to produce an ion pair, the differential omega value, backscatter coefficients, different types of mass ranges, and stopping powers were determined. A comparison of our experimental results with those of the calculations shows a very satisfactory agreement in the whole energy range. In addition to these data some quantities of interest in the fields of radiation biology and microdosimetry, such as the statistical fluctuation of ionization yields, the energy transfer to and the ionization yields in thin material layers of the tissue equivalent gas, together with the distance distribution of energy transfer and the dose average of the specific energy, have been studied. A comparison of these results with those for electrons in water showed the great similarity of both stopping media for many purposes in the fields of radiation research.
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http://dx.doi.org/10.1088/0031-9155/37/5/008 | DOI Listing |
World J Oncol
February 2025
Comprehensive Breast Health Center, Department of Surgery, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
Background: While mutations in the gene play important roles in human breast carcinogenesis, gene alterations are recognized as actionable mutations for clinical cancer treatment. We aimed to elucidate the role of PIK3R1 in cell proliferation on breast carcinoma and to correlate the PIK3R1 expression with patients' outcome using human tumor tissue arrays.
Methods: Using human BT-474 (estrogen receptor (ER)+/human epidermal growth factor receptor 2 (HER2)-high) breast carcinoma cell line as model, the role of PIK3R1 in cell proliferation was elucidated by knock-down of the gene (ΔPIK3R1) in this cell line.
Cureus
December 2024
Department of Radiology, Aichi Medical University, Nagakute, JPN.
Purpose In linac-based stereotactic radiosurgery (SRS) utilizing a multileaf collimator (MLC) for brain metastases (BMs), a volumetric-modulated arc (VMA) technique is indispensable for generating a suitable dose distribution with efficient planning and delivery. However, the optimal calculation grid spacing (GS) and statistical uncertainty (SU) of the Monte Carlo algorithm for VMA optimization have yet to be determined. This planning study aimed to examine the impacts of GS and GU settings on VMA-based SRS planning and to find the optimal combination for templating.
View Article and Find Full Text PDFInvest Radiol
January 2025
From the Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (A. Schwarz, A. Simon, A.M.); Siemens Healthineers AG, Forchheim, Germany (A. Schwarz, C.H., J.D., A. Simon); Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany (F.K.W., S.G., M.S.); and Institut for Radiology, Pediatric and Neuroradiology, Helios Hospital, Schwerin, Germany (H.-J.R.).
Objective: Respiratory motion can affect image quality and thus affect the diagnostic accuracy of CT images by masking or mimicking relevant lung pathologies. CT examinations are often performed during deep inspiration and breath-hold to achieve optimal image quality. However, this can be challenging for certain patient groups, such as children, the elderly, or sedated patients.
View Article and Find Full Text PDFActa Ophthalmol
January 2025
Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Aims: Childhood cancer is a risk factor for cardiovascular diseases in later life. Retinal examination allows to non-invasively observe the vasculature of an end-organ. We observe alterations in long-term childhood cancer survivors (CCS).
View Article and Find Full Text PDFBackground: While concomitant opioid and benzodiazepine use is discouraged due to an increased risk of sedation/overdose, the extent of perioperative opioid utilization in hand surgery patients already using benzodiazepines is unknown.
Methods: Using an administrative claims database, we identified adults undergoing carpal tunnel, DeQuervain, or trigger finger release, palmar fasciectomies, ganglion/mucoid cyst removals, and hand/wrist soft tissue mass excisions from 2011 to 2021. We identified opioid-naive patients with a benzodiazepine prescription within 90 days before surgery.
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