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Optical Flow-Enhanced Mamba U-Net for Cardiac Phase Detection in Ultrasound Videos.
IEEE Trans Med Imaging
March 2025
The detection of cardiac phase in ultrasound videos, identifying end-systolic (ES) and end-diastolic (ED) frames, is a critical step in assessing cardiac function, monitoring structural changes, and diagnosing congenital heart disease. Current popular methods use recurrent neu ral networks to track dependencies over long sequences for cardiac phase detection, but often overlook the short-term motion of cardiac valves that sonographers rely on. In this paper, we propose a novel optical flow-enhanced Mamba U-net framework, designed to utilize both short-term motion and long-term dependencies to detect the cardiac phase in ultrasound videos.
View Article and Find Full Text PDFCellular Senescence in the Regenerative Niche Hampers Skeletal Muscle Repair.
Aging Dis
March 2025
Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou, China.
With the growing interest in skeletal muscle diseases, understanding the processes, factors, and treatments associated with muscle regeneration is crucial. Skeletal muscle regeneration is a complex process that largely depends on the niche composed of cell populations, such as satellite cells, and their microenvironment. Cellular senescence is associated with various physiological processes and age-related diseases and plays a significant role in the muscle regeneration niche.
View Article and Find Full Text PDFPro-Fibrotic Macrophage Subtypes: SPP1+ Macrophages as a Key Player and Therapeutic Target in Cardiac Fibrosis?
Cells
February 2025
Department of Anesthesiology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Cardiac fibrosis is a major driver of heart failure, a leading cause of morbidity and mortality worldwide. Advances in single-cell transcriptomics have revealed the pivotal role of SPP1+ macrophages in the pathogenesis of cardiac fibrosis, positioning them as critical mediators and promising therapeutic targets. SPP1+ macrophages, characterized by elevated expression of () and often co-expressing (), localize to fibrotic niches in the heart and other organs.
View Article and Find Full Text PDFDevelopment and validation of the sarcopenia composite index: A comprehensive approach for assessing sarcopenia in the ageing population.
Ann Acad Med Singap
February 2025
Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan.
Introduction: The diagnosis of sarcopenia relies on key indicators such as handgrip strength, walking speed and muscle mass. Developing a composite index that integrates these measures could enhance clinical evaluation in older adults. This study aimed to standardise and combine these metrics to establish a z score for the sarcopenia composite index (ZoSCI) tailored for the ageing population.
View Article and Find Full Text PDFDifficult Airway Management in Oromaxillofacial Tumor Surgery: Two Case Reports and Review of the Literature.
Indian J Otolaryngol Head Neck Surg
February 2025
Basaksehir Cam and Sakura City Hospital, Başakşehir, Istanbul, Turkey.
Difficult airway management in oromaxillofacial tumor surgery poses significant challenges for anesthesiologists. We present two case reports of patients with mandibular malignant tumors and maxillary osteosarcoma who underwent surgery under general anesthesia. Preoperative assessment revealed a mass involving the right mandible, completely covering the inside of the mouth and invading the floor of the mouth in the first case, and a mass in the left maxilla extending to the zygomatic arch and orbital floor in the second case.
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