AI Article Synopsis
- Atopic dermatitis of the head and neck (HNAD) is linked to Malassezia furfur, a yeast that may trigger allergic reactions.
- The study aimed to assess the relationship between IgE antibodies against M. furfur and the severity of HNAD symptoms.
- Results showed a strong correlation between higher levels of these antibodies and more severe disease symptoms, indicating that measuring IgE anti-M. furfur could help assess HNAD severity.
Article Abstract
Background: Atopic dermatitis of the head and neck (HNAD) has been recognized as a separate entity. Malassezia furfur, a lipophilic yeast, is considered to be a pathogenic allergen in this form of atopic dermatitis.
Objective: The purpose of this study was to determine the level of IgE anti-M.-furfur antibodies and their relation to the severity of the disease.
Methods: IgE anti-M.-furfur antibodies were assayed in 106 patients with HNAD. Controls included 25 patients with non-HNAD, 20 with nonatopic dermatitis and 16 with seborrheic dermatitis (including 4 with AIDS).
Results: There was a highly significant correlation between the level of anti-M.-furfur IgE and clinical severity. Furthermore, there was a significant but smaller correlation between total IgE and clinical severity. In patients with HNAD, total IgE was higher amongst men.
Conclusion: IgE anti-M.-furfur antibodies are a good and specific marker for HNAD. IgE M. furfur levels are strongly correlated with the severity of the disease.
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| http://dx.doi.org/10.1159/000086438 | DOI Listing |
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