Frontotemporal dementia with ubiquitinated neuronal inclusions and visuospatial impairment.

Neurology

Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Published: August 2005

Dementia with ubiquitinated neuronal inclusions has been described only with frontotemporal dementia (FTD). The authors report a patient with progressive FTD accompanied by prominent impairments in visuospatial cognitive functions. Pathology was characterized by ubiquitin-positive intranuclear and cytoplasmic neuronal inclusions. Cortical pathology was widespread and posteriorly accentuated but spared the hippocampal dentate gyrus.

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http://dx.doi.org/10.1212/01.wnl.0000171347.28558.56DOI Listing

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