Male Microtus arvalis mice from radionuclide polluted territories in the South Urals (90Sr activity of ground--0.2, 2, 500, 800 Ci/km2) were used. The 90Sr content in a mouse bony skeleton was determined. Carbohydrate, energy and protein metabolism, lipid peroxidation processes in liver were studied. The intensification of protein and carbohydrate enzymes. On the increase of antioxidant activity we found the reduction of lipid peroxidation processes. The decrease of microsome oxidoreductases was found. Possible mechanisms of the observed effects are discussed.
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Pharmaceutics
December 2024
Department of General Surgery, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, China.
Background/objectives: Colorectal cancer (CRC) is characterized by a high rate of both incidence and mortality, and its treatment outcomes are often affected by recurrence and drug resistance. Ferroptosis, an iron-dependent programmed cell death mechanism triggered by lipid peroxidation, has recently gained attention as a potential therapeutic target. Graphene oxide (GO), known for its oxygen-containing functional groups, biocompatibility, and potential for functionalization, holds promise in cancer treatment.
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December 2024
Department of Pharmacology, and Toxicology, and Biochemistry, Faculty of Pharmacy, Future University in Egypt, Cairo 11865, Egypt.
Skin wrinkles result from a myriad of multifaceted processes involving intrinsic and extrinsic aging. To combat this effect, plant stem cells offer a renewable and eco-friendly source for various industries, including cosmeceuticals. (SM), which contains the bioactive compound Rosmarinic acid (RA) and has been proposed for its anti-wrinkle effect.
View Article and Find Full Text PDFPlants (Basel)
December 2024
Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, Chiyoda, Tokyo 102-8554, Japan.
Flooding causes severe yield losses worldwide, making it urgent to enhance crop tolerance to this stress. Since natural flooding often involves physical flow, we hypothesized that the effects of submergence on plants could change when combined with physical flow. In this study, we analyzed the growth and transcriptome of exposed to submergence or flooding with physical flow.
View Article and Find Full Text PDFToxics
December 2024
Bioengineering Laboratory, ISEP, Polytechnic of Porto, Rua Dr António Bernardino de Almeida, 431, 4249-015 Porto, Portugal.
This work aimed to characterize the impact of copper (Cu), at environmentally relevant concentrations, using the freshwater microalga . Algae were incubated with 33 or 53 µg/L Cu, in OECD medium, and toxic impacts were evaluated over 72 h, using different cellular and biochemical biomarkers. The exposure to 33 µg/L Cu had an algistatic effect: slowing growth and reducing algal population (53%, at 72 h) without compromising the cell membrane.
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December 2024
Division of Pharmaceutical Biotechnology, Department of Pharmaceutical Biology and Biotechnology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
L. (Malabar spinach, Basellaceae), widely consumed as a leafy vegetable, produces dark-colored fruits rich in betacyanins, including rare 6-glycosylated derivatives called gomphrenins. Comprehensive studies on the anti-inflammatory potential of its gomphrenin fraction (A) and crude extract (B) employed various analytical and biological methods.
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