[Expression and clinical significance of nm23-H1, Fas and FasL in colorectal carcinoma tissues].

Objective: To investigate the expression and clinical significance of nm23-H1, Fas and FasL in colorectal carcinoma tissues.

Methods: The expression levels of nm23-H1, Fas and FasL in 48 cases of colorectal carcinoma tissues and 15 cases of normal colorectal tissues were determined by SP immunohistochemical staining.

Results: Positive expression rates of nm23-H1, Fas and FasL in colorectal carcinoma were (25.0 +/- 2.6)%, (41.7 +/- 2.7) and (77.1 +/- 2.7)% respectively; the positive expression rates of nm23-H1 and Fas were lower than that in the normal colorectal tissues (P<0.01); the FasL expression rate in colorectal carcinoma tissues was higher than that in the normal colorectal tissues (P<0.01); the lower expression of nm23-H1 and Fas, and the higher expression of FasL in colorectal carcinoma were correlated with the type of carcinoma histology, lymph node metastasis, Dukes' stage and prognosis (P<0.01).

Conclusion: These results suggest that the lower expression of nm23-H1 and Fas and higher expression of FasL may be used as a good indicator in evaluating lymph node metastasis and prognosis.