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Preventive breast health care, an embarrassing subject for women with intellectual disability.
J Intellect Disabil
March 2025
Department of Public Health and Caring Science, Uppsala University, Sweden.
BackgroundWomen with intellectual disability run an increased risk of dying of breast cancer compared to the general population. There is a clear connection between late detection and low participation in the mammogram screening program. This study aimed to explore the views and experiences of breast health care in women with intellectual disability.
View Article and Find Full Text PDFI Hope So Too.
J Clin Oncol
March 2025
Department of Supportive Oncology, Dana-Farber Cancer Institute, Boston, MA.
Even in our most difficult moments as clinicians, we can find space to hope with our patients, if we look for it. Dr Richard Leiter tells the powerful story of caring for a young man dying of GVHD.
View Article and Find Full Text PDFAnastasis and Other Apoptosis-Related Prosurvival Pathways Call for a Paradigm Shift in Oncology: Significance of Deintensification in Treating Solid Tumors.
Int J Mol Sci
February 2025
Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, AB T6G 1Z2, Canada.
What is apoptosis? The Nomenclature Committee on Cell Death and numerous other pioneering cancer/p53 biologists use the terms "apoptosis" and "cell death" interchangeably, disregard the mind-numbing complexity and heterogeneity that exists within a tumor (intratumor heterogeneity), disregard the contribution of polyploid giant cancer cells (PGCCs; the root causes of therapy resistance and relapse) to this heterogeneity, and then propose novel apoptosis-stimulating anticancer strategies. This is shocking for the following three reasons. First, clinical studies reported since the 1990s have revealed that increased apoptosis in solid tumors is associated with increased tumor diversity and poor prognosis.
View Article and Find Full Text PDFUnveiling the cancer epidemic in India: a glimpse into GLOBOCAN 2022 and past patterns.
Lancet Reg Health Southeast Asia
March 2025
Division of Implementation Research, Indian Council of Medical Research (ICMR), Headquarters, New Delhi, 110029, India.
Background: The Global Cancer Observatory (GLOBOCAN) 2022 estimates highlight cancer as a significant global health problem. In the South-East Asia-region, India ranks third in terms of cancer incidence, second for mortality, and 121 in terms of crude rates globally. As cancer risks increase with age, particularly affecting older individuals, this study explores the current cancer burden in India by analyzing the cancer landscape across different age groups, determining the population's risk of cancer diagnosis and death, and projecting the future cancer burden aligned with past mortality patterns.
View Article and Find Full Text PDFLow responsiveness of machine learning models to critical or deteriorating health conditions.
Commun Med (Lond)
March 2025
Department of Computer Science and Sanghani Center for AI and Data Analytics, Virginia Tech, Blacksburg, VA, USA.
Background: Machine learning (ML) based mortality prediction models can be immensely useful in intensive care units. Such a model should generate warnings to alert physicians when a patient's condition rapidly deteriorates, or their vitals are in highly abnormal ranges. Before clinical deployment, it is important to comprehensively assess a model's ability to recognize critical patient conditions.
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