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Low-dose titrated amitriptyline as second-line treatment for adults with irritable bowel syndrome in primary care: the ATLANTIS RCT.
Health Technol Assess
October 2024
Clinical Trial Research Unit, Leeds Institute of Clinical Trials Research, School of Medicine, University of Leeds, Leeds, UK.
Article Synopsis
- - The study aims to assess the effectiveness and cost-efficiency of low-dose amitriptyline as a second-line treatment for patients with irritable bowel syndrome (IBS) in primary care, especially when first-line treatments fail.
- - Conducted as a pragmatic, double-blind, placebo-controlled trial across 55 general practices in England, the design included both quantitative outcomes and qualitative experiences from participants and general practitioners regarding the treatment.
- - Participants included adults over 18 diagnosed with IBS who did not respond to initial therapies; they received either amitriptyline or a placebo for 6 months, with a focus on measuring the difference in IBS symptoms to see if the medication has a significant impact.
A focused update to the 2019 NLA scientific statement on use of lipoprotein(a) in clinical practice.
J Clin Lipidol
June 2024
Department of Medicine, Baylor College of Medicine, Houston, TX, USA (Dr Ballantyne). Electronic address:
Since the 2019 National Lipid Association (NLA) Scientific Statement on Use of Lipoprotein(a) in Clinical Practice was issued, accumulating epidemiological data have clarified the relationship between lipoprotein(a) [Lp(a)] level and cardiovascular disease risk and risk reduction. Therefore, the NLA developed this focused update to guide clinicians in applying this emerging evidence in clinical practice. We now have sufficient evidence to support the recommendation to measure Lp(a) levels at least once in every adult for risk stratification.
View Article and Find Full Text PDFLet's Focus on the Fibrosis in Dupuytren Disease: Cell Communication Network Factor 2 as a Novel Target.
J Hand Surg Glob Online
September 2023
Department of Biomedical Education and Data Science, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Dupuytren disease is a progressive, benign fibroproliferative disorder of the hands that can lead to debilitating hand contractures. Once symptomatic, treatment involves either surgical intervention, specifically fasciectomy or percutaneous needle aponeurotomy, or enzymatic degradation with clostridial collagenase. Currently, collagenase is the only pharmacotherapy that has been approved for the treatment of Dupuytren contracture.
View Article and Find Full Text PDFX-Let's Atom Combinations for Modeling and Denoising of OCT Images by Modified Morphological Component Analysis.
IEEE Trans Med Imaging
February 2024
An improved analysis of Optical Coherence Tomography (OCT) images of the retina is of essential importance for the correct diagnosis of retinal abnormalities. Unfortunately, OCT images suffer from noise arising from different sources. In particular, speckle noise caused by the scattering of light waves strongly degrades the quality of OCT image acquisitions.
View Article and Find Full Text PDFModeling and optimal control applied to reduce the effects of greenhouse gases emitted from the coal-based power plant in Bangladesh.
Heliyon
August 2023
Mathematics Discipline, Science Engineering and Technology School, Khulna University, Khulna, 9208, Bangladesh.
Article Synopsis
- The coal-fired power station is a major source of carbon dioxide emissions, contributing to climate change and threatening the Sundarbans mangrove forest.
- A compartmental mathematical model was developed to analyze greenhouse gas emissions and the effectiveness of two control strategies: a chemical reactor system and natural afforestation.
- The study found that both strategies reduce pollution, but the chemical reactor system is deemed the best option due to its higher reaction rate and associated costs.
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