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The Biological Properties of Co-Doped Monetite Are Influenced by Thermal Treatment.
J Biomed Mater Res B Appl Biomater
February 2025
Bioassays and Cellular Dynamics Lab, Department of Chemical and Biological Sciences, Institute of Biosciences, UNESP: São Paulo State University, São Paulo, Brazil.
Calcium phosphates, notably monetite, are valued biomaterials for bone applications owing to their osteogenic properties and rapid uptake by bone cells. This study investigates the enhancement of these properties through Cobalt doping, which is known to induce hypoxia and promote bone cell differentiation. Heat treatments at 700°C, 900°C, and 1050°C are applied to both monetite and Cobalt-doped monetite, facilitating the development of purer, more crystalline phases with varied particle sizes and optimized cellular responses.
View Article and Find Full Text PDFRNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells.
J Exp Med
March 2025
Division of Innate Immunity, The Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.
Lysosomal stress due to the accumulation of nucleic acids (NAs) activates endosomal TLRs in macrophages. Here, we show that lysosomal RNA stress, caused by the lack of RNase T2, induces macrophage accumulation in multiple organs such as the spleen and liver through TLR13 activation by microbiota-derived ribosomal RNAs. TLR13 triggered emergency myelopoiesis, increasing the number of myeloid progenitors in the bone marrow and spleen.
View Article and Find Full Text PDFAutologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth Factors.
J Funct Biomater
January 2025
Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.
Aim: This review aims to explore the clinical applications, biological mechanisms, and potential benefits of concentrated growth factors (CGFs), autologous materials, and xenografts in bone regeneration, particularly in dental treatments such as alveolar ridge preservation, mandibular osteonecrosis, and peri-implantitis.
Materials And Methods: A systematic literature search was conducted using databases like PubMed, Scopus, and Web of Science, with keywords such as "bone regeneration" and "CGF" from 2014 to 2024. Only English-language clinical studies involving human subjects were included.
Evaluation of Extra-High Translucent Dental Zirconia: Translucency, Crystalline Phase, Mechanical Properties, and Microstructures.
J Funct Biomater
January 2025
Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8549, Japan.
Highly translucent zirconia (TZ) is frequently used in dentistry. The properties of several highly translucent zirconia materials available in the market require an in-depth understanding. In this study, we assessed the translucency, crystalline phase, mechanical properties, and microstructures of three newly developed highly translucent zirconia materials (Zpex 4.
View Article and Find Full Text PDFImpact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence.
Metabolites
January 2025
Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, 95124 Catania, Italy.
Periodontitis, a chronic multifactorial inflammatory condition of the periodontium, is originated by a dysbiotic oral microbiota and is negatively correlated with several systemic diseases. The low-chronic burden of gingival inflammation not only exacerbates periodontitis but also predisposes individuals to a spectrum of age-related conditions, including cardiovascular diseases, neurodegenerative disorders, and metabolic dysfunction, especially related to ageing. In this regard, over the local periodontal treatment, lifestyle modifications and adjunctive therapies may offer synergistic benefits in ameliorating both oral and systemic health in ageing populations.
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