Objective: To investigate the effect of Qingikailing and Shengmai injection alone or combined on the acute lung injury (AL) induced by oleic acid in rabbits.
Method: The rabbits were randomly divided into 11 groups: oleic acid group; control group; treatment groups including low, middle and high dosage groups of Qingkailing and Shengmai injection alone and combined, respectively. ALI model was established by iv oleic acid (0.05 mL x kg(-1)) in these groups, and then iv above drugs respectively,while in control group, the same volume of normal saline was given. The respiratory amplitude and rate were observed, and blood samples were taken from cervical artery for blood-gas analysis before and at 30, 60, 120 min after oleic acid or normal saline administration. At the end of experiment, the concentration of LDH, CAT and MDA in the lung tissue were measured and pathologic changes of lung tissue were observed microscopically.
Result: Compared with oleic acid group, the respiratory amplitude markedly enhanced (P < 0.05) in the low and high dose groups of Qingkailing and Shengmai injection. PaO2 increased significantly (P < 0.05) in the low dose group of combined Qingkailing and Shengmai injection, PaCO2 decreased markedly (P < 0.05) in the low dose groups of Qingkailing and Shengmai injection alone and combined. The level of MDA significantly decreased (P < 0.05) in the each group of Qingkailing and Shengmai injection alone, the level of MDA significantly decreased (P < 0.05) and CAT increased (P < 0.05) in the low dose group of combined Qingkailing with Shengmai injection. The low dose group of combined Qingkailing and Shengmai injection can alleviate the pathological changes induced by oleic acid.
Conclusion: The curative effect of the low dose group of combined Qingkailing with Shengmai injection for the ALI induced by oleic acid was better than Qingkailing and Shengmai injection alone at the same dosage.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
[Network Meta-analysis of comparative efficacy of Chinese medicine injections for dilated cardiomyopathy].
Zhongguo Zhong Yao Za Zhi
November 2024
Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China.
Bayesian network Meta-analysis was conducted to assess the efficacy and safety of different Chinese medicine injections for dilated cardiomyopathy(DCM). CNKI, Wanfang, VIP, SinoMed, PubMed, Web of Science, EMbase, Cochrane Library, ProQuest, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov were searched for the randomized controlled trial(RCT) from the inception to January 2024.
View Article and Find Full Text PDFComparative efficacy of Chinese tonic medicines for treating sepsis or septic shock: A systematic review and Bayesian network meta-analysis of randomized controlled trials.
Phytomedicine
November 2024
West China Center of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address:
Background: Sepsis or septic shock is a life-threatening medical emergency with a poor prognosis and a high economic burden for both individuals and healthcare resources. Evidence suggests that Chinese tonic medicines (CTMs), as adjuvant treatments, are effective in treating this disease. Nevertheless, the ongoing discourse regarding the optimal CTMs persists.
View Article and Find Full Text PDFStudy on the mechanism of Shenmai injection in the treatment of sepsis.
J Cell Mol Med
November 2024
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Article Synopsis
- Shenmai injection (SMI) is commonly used to treat sepsis, and this study investigates its unclear molecular mechanism using advanced tech like network pharmacology and molecular docking.* -
- Researchers identified 122 potential therapeutic targets and 28 key targets, with findings highlighting the PI3K-AKT, RAP1, and MAPK signaling pathways as significantly enriched.* -
- The study reveals that SMI may work through multiple targets related to anti-inflammatory, anti-oxidative, and immune regulation processes, offering insights for future sepsis research.*
Brucea javanica Seed Oil Emulsion and Shengmai Injections Improve Peripheral Microcirculation in Treatment of Gastric Cancer.
Chin J Integr Med
September 2024
Department of Cardiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Objective: To explore and verify the effect and potential mechanism of Brucea javanica Seed Oil Emulsion Injection (YDZI) and Shengmai Injection (SMI) on peripheral microcirculation dysfunction in treatment of gastric cancer (GC).
Methods: The potential mechanisms of YDZI and SMI were explored through network pharmacology and verified by cellular and clinical experiments. Human microvascular endothelial cells (HMECs) were cultured for quantitative real-time polymerase chain reaction, Western blot analysis, and human umbilical vein endothelial cells (HUVECs) were cultured for tube formation assay.
Effect of shenmai injection on anthracycline-induced cardiotoxicity: A systematic review and meta-analysis.
Complement Ther Med
August 2024
School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu, China; Gansu Pharmaceutical Industry Innovation Research Institute, Lanzhou, Gansu, China. Electronic address:
Objective: Shenmai injection is a classic herbal prescription, and is often recommended for the treatment of anthracycline-induced cardiotoxicity. However, the efficacy and safety of Shenmai injection for the treatment of anthracycline-induced cardiotoxicity have not been reported.
Materials And Methods: We conducted a comprehensive search of eight literature databases and two clinical trial registries, retrieving all randomized controlled trials (RCTs) related to the treatment of anthracycline-induced cardiotoxicity with Shenmai injection from the establishment of the databases to July 1, 2023.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!